Blood Lipids in Brain Infarction Subtypes
| Autor: | Eric Bruckert, Pierre Amarenco, Julien Labreuche, Fathi Driss, Assia Jaillard, Pierre-Jean Touboul, Alexis Elbaz |
|---|---|
| Přispěvatelé: | Recherches épidémiologiques en neurologie et psychopathologie, Institut National de la Santé et de la Recherche Médicale (INSERM), Service de biochimie hormonale, métabolique et génétique, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Département de neurologie, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Service d’Endocrinologie, Métabolisme et Prévention des Risques Cardio-Vasculaires [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Tzourio, Christophe, Service d'Endocrinologie, Métabolisme et Prévention des Maladies Cardio-vasculaires [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU) |
| Rok vydání: | 2006 |
| Předmět: |
Male
Apolipoprotein B MESH: Apolipoprotein A-I Blood lipids 030204 cardiovascular system & hematology Gastroenterology chemistry.chemical_compound MESH: Cholesterol 0302 clinical medicine Risk Factors MESH: Risk Factors MESH: Peptide Fragments Stroke Hypercholesterolaemia MESH: Aged MESH: Middle Aged biology Cerebral infarction MESH: Hypercholesterolemia Middle Aged MESH: Apolipoproteins B Cholesterol Neurology Cardiology Female [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] lipids (amino acids peptides and proteins) MESH: Cholesterol HDL Cardiology and Cardiovascular Medicine Lacunar infarction MESH: Cholesterol LDL Brain Infarction medicine.medical_specialty Lacunar stroke Hypercholesterolemia 03 medical and health sciences MESH: Cross-Sectional Studies MESH: Brain Infarction Internal medicine Carotid stenosis medicine Humans [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Aged Apolipoproteins B MESH: Humans Apolipoprotein A-I business.industry Cholesterol HDL Cholesterol LDL Odds ratio Atherosclerosis medicine.disease Peptide Fragments MESH: Male Confidence interval Cross-Sectional Studies chemistry [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie biology.protein [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie Neurology (clinical) business MESH: Female 030217 neurology & neurosurgery |
| Zdroj: | Cerebrovascular Diseases Cerebrovascular Diseases, Karger, 2006, 22 (2-3), pp.101-8. ⟨10.1159/000093237⟩ |
| ISSN: | 1421-9786 1015-9770 |
| DOI: | 10.1159/000093237 |
| Popis: | Background: Little is known about the relationship between hypercholesterolaemia and specific aetiological subtypes of brain infarction (BI). Methods: In a cross-sectional study of 492 pairs of patients with a BI proven by MRI and matched hospital controls, we determined the blood levels of triglycerides, total, HDL and LDL cholesterol, and apolipoprotein A1 and B, in the same centralized laboratory. We performed aetiological BI subtype classification. Results: Except for triglycerides, the risk of BI increased continuously with the lipid levels, without any heterogeneity between the main BI subtypes or the group on lipid-lowering therapy. The adjusted odds ratio per standard deviation in LDL cholesterol (0.93 mmol/l) was 1.74 (95% confidence interval, 1.02–2.98) in atherothrombotic strokes (n = 109) and 2.71 (95% confidence interval, 1.60–4.55) in lacunar strokes (n = 105). Eighty percent of patients were above the ATP-III guideline threshold LDL cholesterol of 2.59 mmol/l (100 mg/dl), with a major contribution of both atherothrombotic and lacunar stroke subtypes to this group. Conclusions: These findings suggest that blood lipids, particularly total and LDL cholesterol levels, are associated with all subtypes of BI, and that LDL above 2.59 mmol/l is highly prevalent. |
| Databáze: | OpenAIRE |
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