Intrarenal distributions and changes of Angiotensin-converting enzyme and Angiotensin-converting enzyme 2 in feline and canine chronic kidney disease
| Autor: | Mariko Sawa, Sawane Mitani, Hye-Sook Chang, Osamu Yamato, Akira Yabuki |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Pathology Brush border canine Peptidyl-Dipeptidase A urologic and male genital diseases Cat Diseases Renin-Angiotensin System Dogs angiotensin-converting enzyme angiotensin-converting enzyme 2 Internal medicine Renin–angiotensin system medicine Animals Dog Diseases Renal Insufficiency Chronic feline CATS General Veterinary biology Full Paper business.industry Glomerulonephritis Angiotensin-converting enzyme medicine.disease Immunohistochemistry Endocrinology Angiotensin-converting enzyme 2 biology.protein Cats business hormones hormone substitutes and hormone antagonists chronic kidney disease Kidney disease |
| Zdroj: | The Journal of Veterinary Medical Science |
| ISSN: | 1347-7439 |
| Popis: | Angiotensin-converting enzyme (ACE) is a key enzyme in the renin-angiotensin system (RAS). ACE2 is a newly identified member of the RAS. The present immunohistochemical study focused on changes in intrarenal ACE and ACE2 immunoreactivity in feline and canine chronic kidney disease (CKD). ACE immunoreactivity was predominantly observed in the brush border of the proximal tubules in dogs and cats. ACE immunoreactivity was lower in CKD kidneys than in normal kidneys, and quantitative analysis demonstrated negative correlations between ACE and renal tissue damage in dogs. ACE2 immunoreactivity was also detected in the proximal tubules; it increased or decreased with CKD in dogs, depending on the renal region assessed. The changes in ACE and ACE2 in CKD were associated with the plasma creatinine concentration in dogs. Findings from dogs with glomerulonephritis were similar to those from dogs with non-glomerulonephritis. The present study suggests that changes in the intrarenal expression of ACE and ACE2 contribute to the pathological mechanisms of canine CKD, but not to the mechanisms of feline CKD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|