Severe Agitation in Dementia: An Explorative Secondary Data Analysis on the Prevalence and Associated Factors in Nursing Home Residents
| Autor: | Debby L. Gerritsen, Armin Ströbel, Rebecca Palm, Bernhard Holle, Christian G.G. Sorg |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty prevalence epidemiology [Dementia] Logistic regression Irritability Euphoriant Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18] 03 medical and health sciences 0302 clinical medicine Prevalence medicine Homes for the Aged Humans Dementia Apathy ddc:610 030212 general & internal medicine Psychiatry Psychomotor Agitation Aged Aged 80 and over business.industry General Neuroscience Secondary data General Medicine medicine.disease Irritable Mood Nursing Homes epidemiology [Psychomotor Agitation] Aggression nursing home Psychiatry and Mental health Clinical Psychology agitation Anxiety Female Geriatrics and Gerontology medicine.symptom business 030217 neurology & neurosurgery Neuropsychiatric Inventory Questionnaire Research Article |
| Zdroj: | Journal of Alzheimer's Disease, 66, 4 (Nov 3), pp. 1463-1470 Journal of Alzheimer's disease 66(4), 1463-1470 (2018). doi:10.3233/JAD-180647 Journal of Alzheimer's Disease Journal of Alzheimer's Disease, 66, 1463-1470 |
| ISSN: | 1875-8908 1387-2877 |
| DOI: | 10.3233/jad-180647 |
| Popis: | Background The phenomena of severe agitation is not well understood and often not adequately treated. Objective This article determines the prevalence and associated factors of severe agitation in nursing home residents with dementia. Methods Secondary data analysis within an observational study in German nursing homes with n = 1,967 participants. We assessed severity of agitation with the Neuropsychiatric Inventory Questionnaire (NPI-Q) and defined the construct of agitation as a composite score of the NPI-Q items agitation/aggression, disinhibition, and irritability/lability; the dependent variable of severe agitation was considered as being present in residents who scored 'severe' in at least one of these symptoms. A binary logistic regression model was calculated to estimate associations. Results The prevalence of severe agitation was 6.3% (n = 124). The strongest associations were found for elation/euphoria (OR 7.6, CI 3.1-18.5), delusions (OR 7.3, CI 4.0-13.2), apathy/indifference (OR 2.8, CI 1.7-4.7), anxiety (OR 2.2, CI 1.2-3.8), nighttime behaviors (OR 2.4, CI 1.4-4.2), motor disturbances (OR 2.4, CI 1.4-4.1), and male sex (OR 2.4. CI 1.3-4.2). Conclusion Severe agitation in nursing home residents with dementia is a relevant clinical issue as approximately 70% of residents have a dementia. Residents with elation/euphoria and delusions may have a stronger risk of showing severe agitation. We consider delusions as a possible cause of agitation and therefore a prelude to agitation. Although it might be possible that elation/euphoria follows from agitation, we hypothesize that the residents first experience elation/ euphoria and exhibit agitation afterwards. |
| Databáze: | OpenAIRE |
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