The effect of near-infrared fluorescence conjugation on the anti-cancer potential of cetuximab
| Autor: | Hu-Jang Lee, Ji Young Yun, Sang-Yoon Nam, Byung-Hwa Hyun, Young Won Yun, Beom-Jun Lee |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Cetuximab-NIRF Body water Near infrared fluorescence 03 medical and health sciences chemistry.chemical_compound Internal medicine medicine A431 cells lcsh:QH301-705.5 neoplasms lcsh:R5-920 Cetuximab Anti-cancer Cancer medicine.disease digestive system diseases 030104 developmental biology Endocrinology medicine.anatomical_structure Paclitaxel chemistry lcsh:Biology (General) near-infrared fluorescence Lean body mass Original Article lcsh:Medicine (General) medicine.drug Blood vessel |
| Zdroj: | Laboratory Animal Research Laboratory Animal Research, Vol 34, Iss 1, Pp 30-36 (2018) |
| ISSN: | 2233-7660 1738-6055 |
| Popis: | This study investigated the anti-cancer potential of a near-infrared fluorescence (NIRF) molecule conjugated with Cetuximab (Cetuximab-NIRF) in six-week-old female BALB/c athymic (nu+/nu+) nude mice. A431 cells were cultured and injected into the animals to induce solid tumors. Paclitaxel (30 mg/kg body weight (BW)), Cetuximab (1 mg/kg BW), and Cetuximab-NIRF (0.25, 0.5 and 1.0 mg/kg BW) were intraperitoneally injected twice a week into the A431 cell xenografts of the nude mice. Changes in BW, tumor volume and weight, fat and lean mass, and diameter of the peri-tumoral blood vessel were determined after two weeks. Tumor volumes and weights were significantly decreased in the Cetuximab-NIRF (1 mg/kg BW) group compared with the control group (P |
| Databáze: | OpenAIRE |
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