Effects of Acute Non-Selective Beta-Adrenergic Blockade on Plasma Ammonia Levels in Exercising Dogs
| Autor: | Jl Pannier, D Matthys, P Calders |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Blood Glucose
Male Catheterization Central Venous medicine.medical_specialty Adrenergic beta-Antagonists Physical Exertion Physical Therapy Sports Therapy and Rehabilitation Physical exercise Propranolol Placebo Placebos Catheters Indwelling Dogs Ammonia Heart Rate Internal medicine Jugular vein Receptors Adrenergic beta Blood plasma medicine Animals Orthopedics and Sports Medicine biology business.industry Fissipedia Antagonist Ultrasonography Doppler biology.organism_classification Blockade Carotid Arteries Glucose Endocrinology Exercise Test Lactates Potassium Jugular Veins business Amino Acids Branched-Chain medicine.drug |
| Zdroj: | International Journal of Sports Medicine. 16:373-377 |
| ISSN: | 1439-3964 0172-4622 |
| DOI: | 10.1055/s-2007-973023 |
| Popis: | The purpose of the present study was to document exercise induced hyperammoniemia after blockade of the beta-adrenoceptors and to investigate the effect of administration of branched-chain amino acids (BCAA) and glucose in these conditions. Seven dogs, chronically instrumented with a catheter in the deep jugular vein and a Doppler probe around the carotid artery were trained to perform a ten-minute treadmill exercise test. Administration of propranolol i.v. prior to exercise increases plasma ammonia at peak exercise compared with placebo (78 +/- 7.9 vs 25 +/- 5.1 mumol/l; p0.05). This effect of propranolol on plasma ammonia during exercise is enhanced by the administration of BCAA (108 +/- 15 vs 78 +/- 7.9 mumol/l; p0.05), and diminished by the administration of glucose (42 +/- 7.7 vs 78 +/- 7.9 mumol/l; p0.05). These results suggest that increased metabolisation of BCAA is involved in the ammonia formation after beta-adrenergic blockade. |
| Databáze: | OpenAIRE |
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