Auditory Fear Conditioning Alters Sensitivity of the Medial Prefrontal Cortex but this is not based on Frequency-dependent Integration
| Autor: | Zhongju Xiao, Haiting Xie, Duobin Wu, Xiaoya Gao, Ningqian Wang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Neurons
0301 basic medicine General Neuroscience Conditioning Classical Prefrontal Cortex Classical conditioning Fear Local field potential Biology Sound intensity Mice 03 medical and health sciences Noise 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Memory Cortex (anatomy) medicine Animals Fear conditioning Prefrontal cortex Neuroscience 030217 neurology & neurosurgery Sensitization |
| Zdroj: | Neuroscience. 442:237-252 |
| ISSN: | 0306-4522 |
| Popis: | Although many studies have shown that the prelimbic (PL) cortex of the mPFC is involved in the formation of conditioned freezing behavior, few have considered the acoustic response characteristics of PL cortex. Importantly, the change in auditory response characteristics of the PL cortex after conditional fear learning is largely unknown. Here we used in vivo cell-attached recordings targeting the mPFC during the waking state. We confirmed that the mPFC of adult C57 mice have neurons that respond to noise and tone in the waking state, especially in the PL cortex. Interestingly, the data also confirmed that these neurons responded well to the intensity of sound but did not have frequency topological distribution characteristics. Furthermore, we found that the number of c-fos positive neurons in the PL cortex increased significantly after auditory fear conditioning. The auditory-induced local field potential recordings and in vivo cell-attached recordings demonstrated that the PL cortex was more sensitive to the auditory conditioned stimulus after the acquisition of conditioned fear. The proportion of neurons responding to noise was significantly increased, and the signal to noise ratio of the spikes were also increased. These data reveal that PL neurons themselves responded to the main information (sound intensity), while the secondary information (frequency) response was almost negligible after auditory fear conditioning. This phenomenon may be the functional basis for handling this type of emotional memory, and this response characteristic is thought to be emotional sensitization but does not change the nature of this response. |
| Databáze: | OpenAIRE |
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