The thalamocortical contribution to epilepsy
| Autor: | William J. Nowack, George C. Theodoridis |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Pharmacology
Cerebral Cortex Epilepsy General Mathematics General Neuroscience Immunology Models Theoretical Models Biological General Biochemistry Genetics and Molecular Biology Computational Theory and Mathematics Thalamus Animals Humans Anticonvulsants General Agricultural and Biological Sciences General Environmental Science |
| Zdroj: | Bulletin of mathematical biology. 53(4) |
| ISSN: | 0092-8240 |
| Popis: | The experimental literature has dealt intensively with the cortical contribution to epilepsy. Possibly because of the direction of technological advance, much less attention has been paid to the role of other structures. A model which emphasizes the role of some of those non-cortical structures, specifically that of thalamocortical modulation of cortical excitability, is developed. Some aspects of the petit mal seizure, a seizure type considered by some investigators to involve thalamocortical mechanisms, are predicted by the model. Although the thalamocortical mechanisms under study are not the only mechanisms underlying seizures, a full understanding of the phenomenology of epilepsy needs to take into account the role of subcortical modification of cortical activities in addition to other mechanisms. Gloor has described two types of epileptogenesis: type I characteristic of non-convulsive seizures and type II characteristics of convulsions. There is disagreement as to whether or not the two mechanisms represent qualitatively different phenomena. Utilizing the thalamocortical model, it can be shown that the two types of epileptogenesis are qualitatively different. Furthermore, the thalamocortical model leads to a possible explanation of clinically different profiles of antiepileptic efficacy of medications. |
| Databáze: | OpenAIRE |
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