Cutting edge: CD4-independent development of functional FoxP3+ regulatory t cells
| Autor: | Sahil Adriouch, Adrien Six, Laurent Drouot, Christophe Arnoult, Sébastien Calbo, Olivier Boyer, Michel Seman, Stéphanie Le Corre, Sophie Dulauroy, Celine A. Blache |
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| Přispěvatelé: | Department of Anatomy, Southern medical university, Canaux calciques , fonctions et pathologies, Université Joseph Fourier - Grenoble 1 (UJF)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Recherche en Génie Civil et Mécanique (GeM), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-École Centrale de Nantes (ECN)-Centre National de la Recherche Scientifique (CNRS), Réseau National des Systèmes Complexes (RNSC), Centre National de la Recherche Scientifique (CNRS)-CPU-CGE-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de la Recherche Agronomique (INRA)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), Laboratoire d'Immunodifférenciation, Université Paris Diderot - Paris 7 (UPD7), Université de Nantes - Faculté des Sciences et des Techniques, Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CGE-CPU-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
CD3 Complex
CD3 Immunology Receptors Antigen T-Cell chemical and pharmacologic phenomena T-Lymphocytes Regulatory Immunophenotyping Mice 03 medical and health sciences 0302 clinical medicine In vivo MHC class I Animals Immunology and Allergy IL-2 receptor 030304 developmental biology Mice Knockout 0303 health sciences biology Histocompatibility Antigens Class II FOXP3 Cell Differentiation Forkhead Transcription Factors hemic and immune systems [SDV.IMM.IMM]Life Sciences [q-bio]/Immunology/Immunotherapy Phenotype In vitro Cell biology Mice Inbred C57BL CD4 Antigens biology.protein Function (biology) 030215 immunology |
| Zdroj: | Journal of Immunology Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2009, 183 (7), pp.4182-6. ⟨10.4049/jimmunol.0901678⟩ Journal of Immunology, 2009, 183 (7), pp.4182-6. ⟨10.4049/jimmunol.0901678⟩ |
| ISSN: | 0022-1767 1550-6606 |
| DOI: | 10.4049/jimmunol.0901678⟩ |
| Popis: | The CD4 coreceptor is mandatory for the differentiation and function of conventional MHC class II-restricted T cells, but little is known about its contribution in regulatory T cells (Tregs). We thus investigated the Treg compartment in mice lacking CD4. CD3+CD8−FoxP3+ cells were readily detected in the periphery of CD4−/− mice, where their percentages were even increased as compared with wild-type animals. These cells had a classical CD25+CD152+GITR+ Treg phenotype, were enriched in memory-type Tregs, and displayed a diversified TCR repertoire. Functionally, CD4−/− Tregs were equally as suppressive as CD4+/+ Tregs in vitro as well as in vivo. Hence, the CD4 coreceptor is dispensable for the generation and function of FoxP3+ Tregs. Furthermore, CD3+CD8−FoxP3+ Tregs were also found to develop in the absence of both CD4 and MHC-II molecules, demonstrating that the generation of Tregs can occur independently of MHC-II recognition. |
| Databáze: | OpenAIRE |
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