Heterogeneity of amygdala response in major depressive disorder: the impact of lifetime subthreshold mania
| Autor: | Jorge R. C. Almeida, Matthew T. Keener, Jay C. Fournier, Benjamin C. Mullin, Mary L. Phillips, Edmund J. LaBarbara, Ellen Frank, Danella Hafeman, Dina M. Kronhaus, Richelle Stiffler |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Bipolar Disorder Emotions Individuality Severity of Illness Index behavioral disciplines and activities Brain mapping Amygdala Functional Laterality Article Neuroimaging mental disorders medicine Humans Bipolar disorder Psychiatry Applied Psychology Psychiatric Status Rating Scales Brain Mapping Depressive Disorder Major Models Statistical medicine.diagnostic_test medicine.disease Magnetic Resonance Imaging Facial Expression Psychiatry and Mental health Mood medicine.anatomical_structure Case-Control Studies Data Interpretation Statistical Major depressive disorder Female medicine.symptom Functional magnetic resonance imaging Psychology Mania Photic Stimulation Clinical psychology |
| Zdroj: | Psychological Medicine. 43:293-302 |
| ISSN: | 1469-8978 0033-2917 |
| DOI: | 10.1017/s0033291712000918 |
| Popis: | BackgroundPatients with major depressive disorder (MDD) present with highly heterogeneous symptom profiles. We aimed to examine whether individual differences in amygdala activity to emotionally salient stimuli were related to heterogeneity in lifetime levels of depressive and subthreshold manic symptoms among adults with MDD.MethodWe compared age- and gender-matched adults with MDD (n = 26) with healthy controls (HC, n = 28). While undergoing functional magnetic resonance imaging, participants performed an implicit emotional faces task: they labeled a color flash superimposed upon initially neutral faces that dynamically morphed into one of four emotions (angry, fearful, sad, happy). Region of interest analyses examined group differences in amygdala activity. For conditions in which adults with MDD displayed abnormal amygdala activity versus HC, within-group analyses examined amygdala activity as a function of scores on a continuous measure of lifetime depression-related and mania-related pathology.ResultsAdults with MDD showed significantly greater right-sided amygdala activity to angry and happy conditions than HC (p p = 0.002).ConclusionsAmong depressed adults with MDD, lifetime features of subthreshold mania were associated with abnormally elevated amygdala activity to emerging happy faces. These findings are a first step toward identifying biomarkers that reflect individual differences in neural mechanisms in MDD, and challenge conventional mood disorder diagnostic boundaries by suggesting that some adults with MDD are characterized by pathophysiological processes that overlap with bipolar disorder. |
| Databáze: | OpenAIRE |
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