Procedural, clinical, and health status outcomes in chronic total coronary occlusion revascularization: Results from the PERSPECTIVE study

Autor: Amin Yehya, Zhen Qian, Jayne Morgan, Sarah Rinehart, John A. Spertus, Harold Carlson, Anna Kalynych, C. Michael Gibson, David E. Kandzari, Bola Ajose, Gerald Chi, Nicholas Lembo, Dimitri Karmpaliotis
Rok vydání: 2019
Předmět:
Male
medicine.medical_specialty
Time Factors
medicine.medical_treatment
Health Status
Population
030204 cardiovascular system & hematology
Revascularization
Prosthesis Design
03 medical and health sciences
0302 clinical medicine
Percutaneous Coronary Intervention
Internal medicine
medicine
Humans
Radiology
Nuclear Medicine and imaging
Zotarolimus
cardiovascular diseases
030212 general & internal medicine
Myocardial infarction
Patient Reported Outcome Measures
Prospective Studies
Registries
education
Aged
Retrospective Studies
Sirolimus
education.field_of_study
business.industry
Percutaneous coronary intervention
Cardiovascular Agents
Drug-Eluting Stents
General Medicine
Recovery of Function
Middle Aged
medicine.disease
Treatment Outcome
Coronary Occlusion
Drug-eluting stent
Conventional PCI
Chronic Disease
Female
Cardiology and Cardiovascular Medicine
business
Mace
medicine.drug
Zdroj: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac AngiographyInterventionsREFERENCES. 96(3)
ISSN: 1522-726X
Popis: BACKGROUND Limited research has detailed the outcomes of chronic total occlusion (CTO) percutaneous coronary intervention (PCI) with independent core laboratory and event adjudication. This study examined procedural, clinical, and patient-reported health status outcomes among patients undergoing CTO PCI with specific focus on outcomes for those treated with zotarolimus-eluting stents (ZES). METHODS Among 500 consecutive patients undergoing attempted CTO PCI, procedural and in-hospital clinical outcomes were examined in addition to the 1-year composite endpoint of death, myocardial infarction, and target lesion revascularization (major adverse cardiac events, MACE). In a pre-specified cohort of 250 patients, health status measures were ascertained at baseline and 1 year. A powered secondary endpoint was 1-year MACE among patients treated with ZES compared with a performance goal. RESULTS Demographic, lesion, and procedural characteristics for the overall population included prior bypass surgery, 29.8%; diabetes, 35.2%; occlusion length >20 mm, 71.3%; J-CTO score, 2.5 ± 1.1; and primary retrograde strategy, 30.8%. Overall guidewire crossing was 90.9%; clinical success following guidewire crossing, 94.3%; and 1-year MACE rate, 12.1%. One-year health status significantly improved from baseline with successful CTO-PCI (angina frequency, 72.7 ± 26.5 at baseline to 96.0 ± 10.8, p
Databáze: OpenAIRE
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