Creation and resolution of non-B-DNA structural impediments during replication

Autor:	Christopher, Mellor, Consuelo, Perez, Julian E, Sale
Rok vydání:	2022
Předmět:	DNA Replication DNA Repair DNA Helicases Humans DNA Saccharomyces cerevisiae Molecular Biology Biochemistry
Zdroj:	Critical Reviews in Biochemistry and Molecular Biology. 57:412-442
ISSN:	1549-7798 1040-9238
Popis:	During replication, folding of the DNA template into non-B-form secondary structures provides one of the most abundant impediments to the smooth progression of the replisome. The core replisome collaborates with multiple accessory factors to ensure timely and accurate duplication of the genome and epigenome. Here, we discuss the forces that drive non-B structure formation and the evidence that secondary structures are a significant and frequent source of replication stress that must be actively countered. Taking advantage of recent advances in the molecular and structural biology of the yeast and human replisomes, we examine how structures form and how they may be sensed and resolved during replication.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af10d765ec19b0d08a5fe256ca5fe1f9 https://doi.org/10.1080/10409238.2022.2121803 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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