Maltodextrin Acceptance and Preference in Eight Mouse Strains
| Autor: | Rachel L. Poole, Hillary T. Ellis, Michael G. Tordoff, Tiffany R. Aleman |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Taste Sucrose Physiology Quantitative Trait Loci Mice Inbred Strains Quantitative trait locus Biology Food Preferences Mice 03 medical and health sciences Behavioral Neuroscience chemistry.chemical_compound Inbred strain Polysaccharides Physiology (medical) Animals 0501 psychology and cognitive sciences 050102 behavioral science & comparative psychology Food science Strain (biology) 05 social sciences food and beverages Maltodextrin Sensory Systems 030104 developmental biology chemistry Sweetening Agents Gustometer Original Article Sucrose intake |
| Zdroj: | Chemical Senses. 41:45-52 |
| ISSN: | 1464-3553 0379-864X |
| DOI: | 10.1093/chemse/bjv056 |
| Popis: | Rodents are strongly attracted to the taste(s) of maltodextrins. A first step toward discovery of the underlying genes involves identifying phenotypic differences among inbred strains of mice. To do this, we used 5-s brief-access tests and 48-h 2-bottle choice tests to survey the avidity for the maltodextrin, Maltrin M040, of mice from 8 inbred strains (129S1/SvImJ, A/J, CAST/EiJ, C57BL/6J, NOD/ShiLTJ, NZO/HlLtJ, PWK/PhJ, and WSB/EiJ). In brief-access tests, the CAST and PWK strains licked significantly less maltodextrin than equivalent concentrations of sucrose, whereas the other strains generally licked the 2 carbohydrates equally. Similarly, in 2-bottle choice tests, the CAST and PWK strains drank less 4% maltodextrin than 4% sucrose, whereas the other strains had similar intakes of these 2 solutions; the CAST and PWK strains did not differ from the C57, NOD, or NZO strains in 4% sucrose intake. In sum, we have identified strain variation in maltodextrin perception that is distinct from variation in sucrose perception. The phenotypic variation characterized here will aid in identifying genes responsible for maltodextrin acceptance. Our results identify C57 × PWK mice or NZO × CAST mice as informative crosses to produce segregating hybrids that will expose quantitative trait loci underlying maltodextrin acceptance and preference. |
| Databáze: | OpenAIRE |
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