Triglycerides as a Metabolic Target in Afrocaribbean Infertile Women with Polycystic Ovary Syndrome
| Autor: | Anne Bachelot, Catherine Moriniere, Jean Vaillant, Charlotte Brouzeng, Guillaume Joguet, Fritz-Line Velayoudom |
|---|---|
| Přispěvatelé: | Laboratoire de Mathématiques Informatique et Applications (LAMIA), Université des Antilles (UA) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
endocrine system diseases Endocrinology Diabetes and Metabolism Population Physiology Black People 030209 endocrinology & metabolism Type 2 diabetes 030204 cardiovascular system & hematology Patient Care Planning 03 medical and health sciences Young Adult 0302 clinical medicine Insulin resistance [MATH.MATH-ST]Mathematics [math]/Statistics [math.ST] Diabetes mellitus Nonalcoholic fatty liver disease Internal Medicine medicine Prevalence Humans Obesity education Triglycerides ComputingMilieux_MISCELLANEOUS Retrospective Studies 2. Zero hunger Hypertriglyceridemia education.field_of_study [STAT.AP]Statistics [stat]/Applications [stat.AP] business.industry nutritional and metabolic diseases [STAT.TH]Statistics [stat]/Statistics Theory [stat.TH] medicine.disease Polycystic ovary female genital diseases and pregnancy complications 3. Good health Caribbean Region Case-Control Studies Female Metabolic syndrome business Infertility Female Polycystic Ovary Syndrome |
| Zdroj: | Metabolic Syndrome and Related Disorders Metabolic Syndrome and Related Disorders, Mary Ann Liebert, 2019, 17 (10), pp.500-504. ⟨10.1089/met.2019.0041⟩ |
| ISSN: | 1540-4196 |
| Popis: | Background: Polycystic ovary syndrome (PCOS) is classically associated with insulin resistance, metabolic syndrome, or type 2 diabetes. Infertile Afrocaribbean (AC) women with PCOS may have metabolic features that could help to better target their management. Objective: To evaluate the characteristics of PCOS in this population and their metabolic profile to target the worst metabolic parameter. Methods: A retrospective study including infertile AC women for 4 years. PCOS was diagnosed using Rotterdam criteria and compared with non-PCOS women referred consecutively for infertility during the same period. Results: Among 981 AC women evaluated for infertility, PCOS was found in 17%. PCOS women were younger than non-PCOS women. After age and body mass index (BMI) matching, only fasting blood glucose and triglyceride levels were higher in PCOS women compared with non-PCOS women. PCOS was positively correlated with triglyceride levels and negatively with vitamin D levels. PCOS women with obesity had low high-density lipoprotein-cholesterol and increased triglyceride levels compared with those without obesity. No correlation was found between lipids or glucose levels and androgen levels. Multivariate analysis showed that only triglycerides were independently related to PCOS after adjustment for age and BMI. Conclusions: In the AC population where the prevalence of obesity and diabetes is increased, the metabolic profile of infertile women with PCOS is mainly characterized by hypertriglyceridemia, with a higher risk of visceral obesity and nonalcoholic fatty liver disease. Interventional studies would be useful to evaluate the predictive value of hypertriglyceridemia on diabetes and cardiovascular diseases in this population. |
| Databáze: | OpenAIRE |
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