The effect of Gd-DTPA on T1-weighted choline signal in human brain tumours
| Autor: | Andrzej S. K. Dzik-Jurasz, Martin O. Leach, Philip S. Murphy, I. J. Rowland |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Gadolinium DTPA
Magnetic Resonance Spectroscopy Biomedical Engineering Biophysics Contrast Media Signal Choline Central nervous system disease chemistry.chemical_compound Gadopentetic acid Glioma Mole medicine Humans Radiology Nuclear Medicine and imaging medicine.diagnostic_test Brain Neoplasms business.industry Water Magnetic resonance imaging Human brain medicine.disease medicine.anatomical_structure chemistry Nuclear medicine business |
| Zdroj: | Magnetic Resonance Imaging. 20:127-130 |
| ISSN: | 0730-725X |
| DOI: | 10.1016/s0730-725x(02)00485-x |
| Popis: | The effect of Gd-DTPA on T-1-weighted choline signal in human brain tumours. The influence of Gd-DTPA on T-1-weighted (T1W) proton MR spectra has been investigated in 19 patients with histologically verified low (n = 13) or high-grade (n = 6) gliomas. Repeat measurements were performed on 9 patients (7 low-grade and 2 high-grade), with 28 examinations performed in total. Comparison of spectra obtained before and after 0.2 mmol/kg Gd-DTPA showed contrast agent induced broadening of the choline signal without significant signal area change. Lack of enhancement of the choline signal with the T-1-weighted acquisitions implies that the contrast agent and the trimethylamine-containing species do not undergo significant direct interaction. Contrast agent induced changes in the choline signal observed in this and previous studies may, therefore, be attributable to T2*/susceptibility-based effects. |
| Databáze: | OpenAIRE |
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