Synthesis of acyclo-C-nucleosides in the imidazo[1,2-a]pyridine and pyrimidine series as antiviral agents

Autor:	Chapat Jp, J. C. Debouzy, Lhassani M, Robert Snoeck, Chavignon O, Teulade Jc, De Clercq E, Myriam Witvrouw, El Mokhtar Essassi, Graciela Andrei, Kerbal A, Elhakmaoui A, A. Gueiffier, Yves Blache, Jan Balzarini
Rok vydání:	1996
Předmět:	Imidazopyridine Pyrimidine Stereochemistry Pyridines viruses Chemical synthesis Antiviral Agents Virus chemistry.chemical_compound Structure-Activity Relationship Drug Discovery Pyridine Chlorocebus aethiops Tumor Cells Cultured Structure–activity relationship Animals Humans Vero Cells Bicyclic molecule virus diseases Nucleosides Pyrimidines chemistry Molecular Medicine Specific activity HeLa Cells
Zdroj:	Journal of medicinal chemistry. 39(14)
ISSN:	0022-2623
Popis:	The synthesis and the antiviral activities of C-3 acyclic nucleoside analogues of imidazo[1,2-a]pyridine and pyrimidine are reported. From these compounds, 20, 21, 22, 23, 28, and 34 showed a specific activity against cytomegalovirus and/or varicella-zoster virus.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af0688e83ac6f0ac0f626fd0b1ada8fd https://pubmed.ncbi.nlm.nih.gov/8709116 Zobrazit plný text záznamu