The combined therapy with chondroitin sulfate plus glucosamine sulfate or chondroitin sulfate plus glucosamine hydrochloride does not improve joint damage in an experimental model of knee osteoarthritis in rabbits
| Autor: | Sergio Portal-Núñez, P. Gratal, Jorge A. Roman-Blas, Raquel Largo, Gabriel Herrero-Beaumont, Aránzazu Mediero, Lidia Tardio |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Cartilage Articular Male medicine.medical_specialty Knee Joint Hydrochloride Glucosamine Sulfate Inflammation Osteoarthritis Pharmacology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Glucosamine Bone Density medicine Animals Drug Interactions Chondroitin sulfate Sulfate 030203 arthritis & rheumatology business.industry Cartilage Chondroitin Sulfates RANK Ligand Synovial Membrane Osteoprotegerin Osteoarthritis Knee medicine.disease Matrix Metalloproteinases Surgery Disease Models Animal 030104 developmental biology medicine.anatomical_structure chemistry Cytokines Rabbits medicine.symptom business |
| Zdroj: | European journal of pharmacology. 794 |
| ISSN: | 1879-0712 |
| Popis: | Osteoarthritis is the most common chronic joint disorder especially during aging. Although with controversies, glucosamine, both in its forms of sulfate and hydrochloride, and chondroitin sulfate are commonly employed to treat osteoarthritis. Due to the modest improve in the symptoms observed in patients treated with these drugs alone, a formulation combining both agents has been considered. The discrepant results achieved for pain control or structural improvement in osteoarthritis patients has been attributed to the quality of chemical formulations or different bias in clinical studies. The current study has been designed to test the effects of two different combined formulations with adequate pharmaceutical grade of these drugs in osteoarthritic joints, and to explore the underlying mechanisms modulated by both formulations in different osteoarthritis target tissues. Knee osteoarthritis was surgically induced in experimental rabbits. Some animals received the combined therapy (CT)1, (chondroitin sulfate 1200mg/day + glucosamine sulfate 1500mg/day), or the CT2 ((chondroitin sulfate 1200mg/day + glucosamine hydrochloride 1500mg/day). Neither CT1 nor CT2 significantly modified the cartilage damage or the synovial inflammation observed in osteoarthritic animals. Treatments were also unable to modify the presence of pro-inflammatory mediators, and the synthesis of metalloproteinases in the cartilage or in the synovium of osteoarthritic animals. Combined therapies did not modify the decrease in the subchondral bone mineral density observed in osteoarthritic rabbits. Therapies of chondroitin sulfate plus glucosamine sulfate or chondroitin sulfate plus glucosamine hydrochloride failed to improve structural damage or to ameliorate the inflammatory profile of joint tissues during experimental osteoarthritis. |
| Databáze: | OpenAIRE |
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