A Systematic Study of the Prevalence and Risk Factors of CKD in Uddanam, India
| Autor: | Geetha Prasadini, Chandra M. Pandey, Balaji Gummidi, Jayaprakash Muliyil, Arpita Ghosh, Gopesh K. Modi, Lakshmy Ramakrishnan, Vijay Kher, Jarnail Singh Thakur, Tripti Khanna, Jawahar Reddy, Oommen John, R S Dhaliwal, Meena Sehgal, Aruna Kumari, Vivekanand Jha, Vishnubhotla Sivakumar, Janardhan C. Reddy, Om P. Kalra |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
hypertension Population 030232 urology & nephrology Renal function 030204 cardiovascular system & hematology urologic and male genital diseases 03 medical and health sciences symbols.namesake chemistry.chemical_compound Uddanam 0302 clinical medicine Clinical Research Internal medicine medicine risk factors Poisson regression Family history education Creatinine education.field_of_study Proteinuria High prevalence business.industry CKD of unknown etiology medicine.disease chemistry Nephrology symbols proteinuria medicine.symptom business chronic kidney disease Kidney disease |
| Zdroj: | Kidney International Reports |
| ISSN: | 2468-0249 |
| Popis: | Introduction Despite reports of a high prevalence of chronic kidney disease (CKD) from the coastal Uddanam region of Andhra Pradesh, India, there are no accurate data on the distribution of kidney function abnormalities and CKD risk factors in this region. Methods A total of 2419 participants were recruited through multistage cluster random sampling from 67 villages. Serum creatinine and urine protein creatinine ratio were measured using validated methodologies. All abnormal estimated glomerular filtration rate (eGFR) and urine protein creatinine ratio values were reconfirmed after 3 months. A range of sociodemographic factors were evaluated for their association with CKD using Poisson regression. Results Of 2402 eligible subjects (mean ± SD age, 45.67 ± 13.29 years; 51% female), 506 (21.07%) had CKD (mean ± SD age, 51.79 ± 13.12 years; 41.3% female). A total of 246 (10.24%) had eGFR 0.15 g/g). The poststratified estimates, adjusted for age and sex distribution of the region for CKD prevalence, are 18.7% (range, 16.4%–21.0%) overall and 21.3% (range, 18.2%–24.4% ) and 16.2% (range, 13.7%–18.8%) in men and women, respectively. Older age, male sex, tobacco use, hypertension, and family history of CKD were independently associated with CKD. Compared with those with higher eGFR, those with eGFR 0.15, except a lower frequency of males in the former. Conclusion We confirmed the high prevalence of CKD in the adult population of Uddanam. The cause was not apparent in a majority. Subjects with a low eGFR with or without elevated proteinuria were phenotypically distinct from those with proteinuria and preserved eGFR. Our data suggest the need to apply a population-based approach to screening and prevention and studies to understand the causes of CKD in this region. Graphical abstract |
| Databáze: | OpenAIRE |
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