Diabetes, the Metabolic Syndrome, and Angiographic Progression of Coronary Arterial Disease in Postmenopausal Women
| Autor: | William T. Cefalu, Philip B. Mellen, David M. Herrington |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
Coronary Artery Disease Type 2 diabetes Coronary Angiography Cohort Studies Predictive Value of Tests Risk Factors Internal medicine Diabetes mellitus medicine Humans Aged Metabolic Syndrome medicine.diagnostic_test Vascular disease business.industry Estrogen Replacement Therapy Type 2 Diabetes Mellitus Estrogens Odds ratio Middle Aged medicine.disease Surgery Postmenopause Diabetes Mellitus Type 2 Angiography Cohort Disease Progression Cardiology Female Metabolic syndrome Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | Arteriosclerosis, Thrombosis, and Vascular Biology. 26:189-193 |
| ISSN: | 1524-4636 1079-5642 |
| Popis: | Objective— Although the metabolic syndrome (MS) is associated with increased cardiovascular risk, its relationship with atherosclerotic progression is less well defined. We sought to determine whether the MS predicts angiographic progression of coronary heart disease in a cohort of postmenopausal women. Methods and Results— A total of 309 postmenopausal women entered the Estrogen Replacement and Atherosclerosis trial, of whom 248 underwent baseline angiography and completed follow-up angiography after an average of 3.2 years. Women were identified as having type 2 diabetes mellitus (T2DM) or the MS (National Cholesterol Education Panel diagnostic criteria). In adjusted models, participants with T2DM and the MS had greater angiographic progression [change in minimal diameter (ΔMD): −0.15] than women without T2DM or the MS (ΔMD: −0.08; P P P =0.54)]. In adjusted logistic regression models, T2DM predicted coronary heart disease events [odds ratio, 2.79 (95% CI, 1.29 to 6.02)], and the MS demonstrated a similar trend [odds ratio, 1.98 (95% CI, 0.90 to 4.33)]. Conclusions— Among postmenopausal women with coronary heart disease, the presence of diabetes predicted disease progression, but the MS did not. |
| Databáze: | OpenAIRE |
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