Toxic epidermal necrolysis induced by methazolamide in a Chinese-Korean man carryingHLA-B*59:01
| Autor: | Chang Shu, Qiuning Sun, Duerna Tie, Rui Zhang, Tong Wang, Yan Yan, Xuming Mao, Qi Dong, Mengqing Yu, Dan Shu |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male China Intraocular pressure medicine.medical_specialty Genotype Methazolamide Dermatology Human leukocyte antigen law.invention Asian People law Republic of Korea Humans Medicine Allele Carbonic Anhydrase Inhibitors Alleles Polymerase chain reaction business.industry Glaucoma medicine.disease HLA-B Toxic epidermal necrolysis HLA-B Antigens Stevens-Johnson Syndrome Immunology business medicine.drug |
| Zdroj: | International Journal of Dermatology. 54:1242-1245 |
| ISSN: | 0011-9059 |
| DOI: | 10.1111/ijd.12651 |
| Popis: | Background Methazolamide is used to lower intraocular pressure in patients with glaucoma. Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) associated with methazolamide treatment have been diagnosed in Korean, Japanese, and Japanese-American patients. According to recent research, the human leukocyte antigen (HLA) allele HLA-B*59:01 is strongly linked to SJS/TEN associated with methazolamide treatment. Objective A patient of Chinese–Korean ethnicity was diagnosed with TEN associated with methazolamide treatment. The purpose of this study was to examine the potential genetic basis of this disease. Methods A polymerase chain reaction sequence-specific primer (PCR-SSP) typing system was used to genotype this patient's peripheral blood DNA for HLA-B*59. Results The genotype HLA-B*59:01 was detected in the patient. Conclusions This study demonstrates the genotype of HLA-B*59:01 in a patient with TEN associated with methazolamide treatment and thus supports the possible correlation between genetic background and methazolamide-associated SJS/TEN. |
| Databáze: | OpenAIRE |
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