An efficient stereoselective and stereodivergent synthesis of (2R,3R)- and (2R,3S)-3-hydroxypipecolic acids

Autor:	Angelique Jourdant, Jieping Zhu
Předmět:	chemistry.chemical_compound Chemistry Stereochemistry Organic Chemistry Drug Discovery Stereoselectivity Piperidine Grignard reagent Biochemistry Combinatorial chemistry
Popis:	Asymmetric syntheses of (2R,3R) and (2R,3S)-3-hydroxypipecolic acids are reported featuring a key diastereoselective addition of Buchi's Grignard reagent to the chiral serinal Image -5. Based on conformational analysis, a stereocontrolled reduction of piperidin-3-one (15) to cis 2,3-disubstituted piperidine (16) is also described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af024cdc6ed9fbaaad3123cf2c69efa0 https://infoscience.epfl.ch/record/158315 Zobrazit plný text záznamu