Anatomic variations and stone formation
| Autor: | Helene Jung, Maria Sloth Pless, Palle Jørn Sloth Osther |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Kidney Calculi/chemistry
Urology 030232 urology & nephrology Kidney medulla Nephrolithiasis Kidney Medulla/abnormalities Urogenital Abnormalities/epidemiology Kidney Calculi 03 medical and health sciences 0302 clinical medicine Urolithiasis Medicine Humans Urolithiasis/epidemiology Kidney Medulla Stone formation business.industry Renal papillary anatomy Endoscopic mapping Anatomic Variation Urogenital Abnormality Spectrometry X-Ray Emission Endoscopy Anatomy X-Ray Microtomography Microcomputed tomography medicine.disease Nephrolithiasis/epidemiology Microscopy Electron Randall's plaque Urogenital Abnormalities 030220 oncology & carcinogenesis Ureteroscopes Kidney stones Stone formers business Crystallization |
| Zdroj: | Jung, H, Pless, M S & Osther, P J S 2018, ' Anatomic variations and stone formation ', Current Opinion in Urology, vol. 28, no. 5, pp. 420-427 . https://doi.org/10.1097/MOU.0000000000000519 |
| DOI: | 10.1097/MOU.0000000000000519 |
| Popis: | PURPOSE OF REVIEW: The pathophysiological mechanisms in kidney stone formation are insufficiently understood. In order to achieve a better understanding of the complexity of stone formation, studies evaluating anatomical variations in the renal papillae have been performed. This review intends to illuminate recent findings. Moreover, new techniques to improve the understanding and interpretation of crystallization mechanisms are reviewed.RECENT FINDINGS: Due to improvements of digital ureteroscopes, detailed endoscopic mapping of renal papillae is now possible. Connections between papillary morphology and histopathological changes in different subsets of stone formers have been documented. The formation of kidney stones seems to take place in relation to Randall's plaques, Ducts of Bellini or by free formation. Additionally, theories of kidney stone formation because of vascular injury or inflammatory events in the papillae have been suggested.SUMMARY: Novel techniques including improved digital endoscopic visualization, microcomputed tomography (CT), electron microscopy and energy dispersive compositional analyses of kidney stones seem essential in the search for effective and reliable methods to understand stone forming processes, which ultimately should result in effective measures for more personalized stone prevention strategies in the future. |
| Databáze: | OpenAIRE |
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