Diagnosis, clinical characteristics, and outcomes of COVID-19 patients from a large healthcare system in northern New Jersey
Autor: | Marcus H Cunningham, Seán Fitzgerald, Caixin Zhan, José R. Mediavilla, Kar Fai Chow, Yanan Zhao, Tao Hong, David S. Perlin, Gary Munk, Steven I. Park, Hee Sang Ahn, Xiangyang Li |
---|---|
Rok vydání: | 2021 |
Předmět: |
Adult
Male medicine.medical_specialty Science Population MEDLINE Diseases 030204 cardiovascular system & hematology Microbiology Article 03 medical and health sciences Medical research 0302 clinical medicine Interquartile range Internal medicine Pandemic Health care Humans Medicine Serologic Tests 030212 general & internal medicine Medical diagnosis education Aged Retrospective Studies Aged 80 and over education.field_of_study Multidisciplinary New Jersey Clinical Laboratory Techniques business.industry COVID-19 Retrospective cohort study Middle Aged Hospitalization Female business Viral load |
Zdroj: | Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021) Scientific Reports |
ISSN: | 2045-2322 |
Popis: | New Jersey was an early epicenter for the COVID-19 pandemic in the United States, yet information on hospitalized COVID-19 patients from this area is scarce. This study aimed to provide data on demographics and clinical features of a hospitalized patient population who were confirmed with infection by our in-house (CDI) real-time reverse-transcription polymerase chain reaction (RT-PCR) test. We included consecutive patients who were admitted to Hackensack Meridian Health system hospitals with laboratory-confirmed diagnoses of COVID-19 at Hackensack University Medical Center by the CDI virus test between March 12, 2020, and April 8, 2020. Clinical data and viral testing results were collected and analyzed for characteristics associated with outcomes, as well as the correlation with viral load. A total of 722 patients were included in the study, with a median age of 63 (interquartile range (IQR), 51–75) and 272 (37.7%) females. Mortality of this case series was 25.8%, with a statistically significant linear increase observed from age 40 to ≥ 80 by 10-year intervals. Viral load, as indicated by the cycle of threshold (Ct) values from the RT-PCR test, was significantly higher in the oldest patient group (≥ 80), and inversely correlated with survival. This is the first report to describe the clinical characteristics and outcomes in a large hospitalized COVID-19 patient series from New Jersey. Findings from this study are valuable to the ongoing response of both nationwide healthcare networks and the medical research community. |
Databáze: | OpenAIRE |
Externí odkaz: |