High diversity of vancomycin-resistant Enterococcus faecium isolated in Southern Brazil

Autor: Jussara L Siqueira, Thiago Gs Paim, Juliana Caierão, Pedro Alves d'Azevedo, Renata de Oliveira Soares, Gustavo Enck Sambrano, Vinícius Pietta Perez, Paul Cos, Gabriela Rosa da Cunha, Guy Caljon
Jazyk: angličtina
Rok vydání: 2019
Předmět:
DOI: 10.7287/peerj.preprints.27817v1
Popis: Background. Vancomycin-resistant enterococci (VRE) are common in some hospital settings and their clonal spread has been described in different regions of the world. We determined the antimicrobial susceptibility profile and the clonal relationship of VRE isolates recovered from inpatients at three general hospitals of Porto Alegre, Brazil. Results. Ninety-four VRE were characterized as Enterococcus faecium and exhibited resistance to teicoplanin, ampicillin, ciprofloxacin, and susceptibility to linezolid, quinupristin-dalfopristin and daptomycin. High level resistance to gentamicin was detected in 13.8% of them. All VREfm harbored vanA gene, while 85.1% and 94.7% harbored respectively esp and acm virulence genes. PFGE profile analysis revealed 23 clonal types including 79 isolates, while 15 isolates exhibited unique pattern type, showing a polyclonal distribution of VREfm in Southern Brazil. Conclusion. These findings contribute to the local understanding regarding the characteristics of the circulating VREs in the region.
Databáze: OpenAIRE