Health risk assessment of exposure to TriCresyl Phosphates (TCPs) in aircraft: A commentary
| Autor: | de Ree, Hans, van den Berg, Martin, Brand, Teus, Mulder, Gerard J, Simons, Ries, Veldhuijzen van Zanten, Brinio, Westerink, Remco H S, LS IRAS Tox Algemeen, Sub IRAS Tox CMT/NTX, Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA1 |
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| Přispěvatelé: | Coronel Institute of Occupational Health, LS IRAS Tox Algemeen, Sub IRAS Tox CMT/NTX, Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA1 |
| Rok vydání: | 2014 |
| Předmět: |
Tri-ortho-Cresyl Phosphate (ToCP)
Aircraft Occupational disease Physiology Inter-individual differences Air Pollutants Occupational Toxicology Risk Assessment Health risk assessment Aerotoxic syndrome Detoxification Cabin air medicine Humans Depression (differential diagnoses) Exposure assessment business.industry General Neuroscience TriCresyl Phosphate (TCP) medicine.disease Hazard quotient Occupational Diseases Tritolyl Phosphates Headaches medicine.symptom business |
| Zdroj: | Neurotoxicology, 45, 209-215. Elsevier NeuroToxicology, 45, 209. Elsevier bedrijfsinformatie b.v. |
| ISSN: | 0161-813X |
| DOI: | 10.1016/j.neuro.2014.08.011 |
| Popis: | Possible exposure to TriCresyl Phosphates (TCPs) has led to concerns among airline crew members. One isomer, Tri-ortho-Cresyl Phosphate (ToCP) is known to be neurotoxic and exposure to ToCP via contaminated cabin air has been suggested to be associated with the alleged Aerotoxic syndrome. The symptoms associated with Aerotoxic syndrome are diverse, including headaches, loss of balance, numbness and neurobehavioral abnormalities such as emotional instability, depression and cognitive dysfunction. Other ortho-isomers are toxic as well, but the non-ortho isomers are regarded as less toxic. In a collaborative effort to increase insight into the possible association between exposure to TCPs via contaminated cabin air and Aerotoxic syndrome, we performed an exposure- and toxicological risk assessment. Measurements in KLM 737 aircraft have demonstrated the presence of non-ortho isomers in low concentrations, though ToCP and other ortho-isomers could not be detected. Based on this exposure assessment, we established a toxicological risk model that also takes into account human differences in bioactivation and detoxification to derive a hazard quotient. From this model it appears unlikely that the health effects and alleged Aerotoxic syndrome are due to exposure to ToCP. Alternative explanations for the reported symptoms are discussed, but evaluation of the current findings in light of the criteria for occupational disease leads to the conclusion that the Aerotoxic Syndrome cannot be regarded as such. Additional research is thus required to unravel the underlying causes for the reported health complaints. |
| Databáze: | OpenAIRE |
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