Investigation of the Relationship Between BK Virus and Human Leukocyte Antigens in Kidney Transplant Recipients
| Autor: | Bilkay Basturk, Miray Kavuzlu, F. Belgin Ataç, H. Eda Alışkan, Bircan Kantaroglu |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_treatment Human leukocyte antigen Opportunistic Infections 030230 surgery medicine.disease_cause Immunocompromised Host 03 medical and health sciences 0302 clinical medicine Immune system Gene Frequency Antigen HLA Antigens medicine Humans Retrospective Studies Polyomavirus Infections Transplantation medicine.diagnostic_test business.industry Immunosuppression Viral Load Kidney Transplantation HLA Mismatch BK virus Tumor Virus Infections Treatment Outcome BK Virus DNA Viral Host-Pathogen Interactions Immunology Female Cytokine secretion business Tissue typing Immunosuppressive Agents |
| Zdroj: | Experimental and Clinical Transplantation. 18:51-54 |
| ISSN: | 2146-8427 1304-0855 |
| DOI: | 10.6002/ect.tond-tdtd2019.o24 |
| Popis: | OBJECTIVES The main function of HLA is to present antigens to lymphocytes and to initiate specific immune responses. Autoimmune, viral, allergic, and neurologic diseases have been found to be related to HLA molecules. In renal transplant, the main target of the recipient's immune system is the HLA molecules on the surface of donor cells. HLA also plays a role in the development of an immune response to viral infections. After renal transplant, BK virus infections may occur due to immunosuppression. Here, we investigated the relationship between HLA and BK virus in renal transplant recipients. MATERIALS AND METHODS This retrospective study investigated HLA-A, HLA-B, and HLA-DR tissue typing before renal transplant. DNA was isolated from whole blood, and tissue typing tests were performed based on polymerase chain reaction. Patients were tested for BK virus posttransplant using DNA isolated from urine and/or plasma samples. RESULTS We found HLA-B*13 allele to be a protective factor (P < .049; odds ratio: 0.131; 95% confidence interval, 0.017-1.029) and HLA-DRB1*03 allele to be a possible risk factor (P < .029; odds ratio: 2.521; 95% confidence interval, 1.157-5.490) against BK virus. No significant relationships were found between BK virus and age, sex, donor type, and HLA mismatch. CONCLUSIONS HLA class I molecules are known to be effective against viruses with the help of cytotoxic T cells. HLA-B*13 alleles within the HLA class I molecules were identified as protective factors against BK virus. HLA class II is associated with CD4-positive T cells that help secrete immune system cytokines, playing a role in stimulating and suppressing the immune system. We demonstrated that HLA-DRB1*03 allele could be a risk factor against BK virus. This allele may be associated with immunomodulatory cytokine secretion of the immune system. |
| Databáze: | OpenAIRE |
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