Urogenital Chlamydia trachomatis Serovars in Men and Women with a Symptomatic or Asymptomatic Infection: an Association with Clinical Manifestations?
| Autor: | P. C. van Voorst Vader, A. J. P. Boeke, A. J. C. Van Den Brule, Christophorus Joannes Lambertus Maria Meijer, Lawrence Rozendaal, G. J. J. Van Doornum, J. Schirm, Servaas A. Morré, I.G.M. van Valkengoed, S. De Blok, J. A. R. Van Den Hoek |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Microbiology (medical) Vaginal discharge Sexually transmitted disease Serotype medicine.medical_specialty Adolescent Chlamydiology and Rickettsiology Population Chlamydia trachomatis Biology medicine.disease_cause Asymptomatic Sex Factors Male Urogenital Diseases Internal medicine medicine Humans Chlamydiaceae Serotyping education Cervix education.field_of_study Age Factors Chlamydia Infections biology.organism_classification Female Urogenital Diseases medicine.anatomical_structure Carrier State Immunology Female medicine.symptom |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1098-660X 0095-1137 |
| DOI: | 10.1128/jcm.38.6.2292-2296.2000 |
| Popis: | To determine whether certain Chlamydia trachomatis serovars are preferentially associated with a symptomatic or an asymptomatic course of infection, C. trachomatis serovar distributions were analyzed in symptomatically and asymptomatically infected persons. Furthermore, a possible association between C. trachomatis serovars and specific clinical symptoms was investigated. C. trachomatis -positive urine specimens from 219 asymptomatically infected men and women were obtained from population-based screening programs in Amsterdam. Two hundred twenty-one C. trachomatis -positive cervical and urethral swabs from symptomatically and asymptomatically infected men and women were obtained from several hospital-based departments. Serovars were determined using PCR-based genotyping, i.e., restriction fragment length polymorphism analysis of the nested-PCR-amplified omp1 gene. The most prevalent C. trachomatis serovars, D, E, and F, showed no association with either a symptomatic or asymptomatic course of infection. The most prominent differences found were (i) the association of serovar Ga with symptoms in men ( P = 0.0027), specifically, dysuria ( P < 0.0001), and (ii) detection of serovar Ia more often in asymptomatically infected people (men and women) ( P = 0.035). Furthermore, in women, serovar K was associated with vaginal discharge ( P = 0.002) and serovar variants were found only in women ( P = 0.045). |
| Databáze: | OpenAIRE |
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