Association Between Blood and Lymphocyte Levels of Cyclosporin A and Infectious Complications in Renal Transplant Patients
| Autor: | Nadine Mefleh, Naja Saber, Aline Milane, Linda Abou-Abbas, Antoine Barbari, Lara Osmani |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
kidney transplant
medicine.medical_specialty Health Toxicology and Mutagenesis Lymphocyte RM1-950 Toxicology Gastroenterology Kidney transplant lymphocyte levels Internal medicine Cyclosporin a medicine cyclosporine Whole blood Kidney Chemical Health and Safety business.industry Public Health Environmental and Occupational Health cytomegalovirus infections medicine.anatomical_structure Renal transplant Original Article Cytomegalovirus infections Therapeutics. Pharmacology urinary tract infections business blood levels |
| Zdroj: | Dose-Response Dose-Response, Vol 19 (2021) |
| ISSN: | 1559-3258 |
| Popis: | Objectives This study aims to investigate a potential association between whole blood and lymphocyte Cyclosporin A (CyA) levels and the occurrence and frequency of infectious complications in kidney transplant patients. Methods The study involves 130 kidney transplant recipients who received CyA in addition to Mycophenolate Mofetil and steroids. CyA whole blood trough and maximum level (CyA BL0 and CyA BLm) as well as the corresponding levels in the lymphocytes (CyA L0 and CyA Lm) were measured for 6 months post-transplantation. Results Cytomegalovirus (CMV) as well as urinary tract infections (UTIs) were the most commonly diagnosed with an incidence of 24.6% and 26.2%, respectively. Only CyA L0 showed a significant association with CMV infection occurrence (adjusted OR = 1.051, 95% CI .997–1.025, P-value 0.046). A positive linear correlation was found between CyA BL0, CyA BLm and CyA Lm and the number of CMV episodes per patient. Conclusion We showed an association between the CMV infections occurrence and the trough lymphocyte level of CyA (CyA L0). Both lymphocyte CyA levels also correlated with the frequency of CMV infections. Further studies are needed to establish the optimal range of both CyA blood and lymphocyte levels and decrease the risk of opportunistic infections in high risk patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |