Renal alterations caused by ligature-induced periodontitis persist after ligature removal in rats
| Autor: | Manoel Dias de Souza Filho, Ivana Márcia Alves Diniz, Daniel Fernando Pereira Vasconcelos, André Luiz dos Reis Barbosa, Silvana P. Barros, Felipe Rodolfo Pereira da Silva, Ana Patrícia de Oliveira, Jand Venes R. Medeiros, Even Herlany Pereira Alves, David Di Lenardo, Marcus Vinícius Oliveira Barros de Alencar, Any Carolina Cardoso Guimarães Vasconcelos, Farahnaz Fahimipou, Hélio Mateus Silva Nascimento, Juliana Gomes Galeno, Luiz Felipe de Carvalho França, Vinícius da Silva Caetano, Paulo Roberto Carneiro Gomes |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty medicine.medical_treatment Alveolar Bone Loss 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Malondialdehyde medicine Animals Rats Wistar Ligature Periodontitis Ligation Dental alveolus Creatinine Kidney business.industry Albumin 030206 dentistry medicine.disease Rats 030104 developmental biology medicine.anatomical_structure Endocrinology chemistry Periodontics Uric acid Histopathology Female business |
| Zdroj: | Journal of periodontal researchREFERENCES. 56(2) |
| ISSN: | 1600-0765 |
| Popis: | Background and objective Periodontitis may crosstalk with renal diseases, yet that remains unclear. We investigated whether the renal alterations caused by induced periodontitis are reversible after removal of the ligatures in experimental ligature-induced periodontitis. Material and methods Twenty-four female rats were divided into three groups: control (without periodontitis), periodontitis (20 days of ligature-induced periodontitis), and P20-20 (20 days of ligature-induced periodontitis and 20 days after ligature removal). The following periodontal parameters were assessed: gingival bleeding index, probing pocket depth, myeloperoxidase activity, and alveolar bone height. For renal tissues, histopathology, malonaldehyde (MDA) levels, glutathione (GSH) content, and renal weight were evaluated. In the blood, creatinine, uric acid, albumin, total cholesterol, total protein, and glucose levels were assessed. Total protein and creatinine levels in urine were also investigated. Results Rat renal tissues did not demonstrate reversal of periodontitis-related changes in the P20-20 group in terms of MDA, GSH, and histopathological evaluations when compared to the periodontitis group. Accordingly, only total cholesterol levels were reversible in the P20-20. Conclusion Renal alterations caused by ligature-induced periodontitis persisted even after removal of ligatures in rats. |
| Databáze: | OpenAIRE |
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