Assessment of sacral spinal excitability using stimulus-response curves of the bulbocavernosus reflex
| Autor: | Claire Hentzen, G. Miget, Nicolas Turmel, Camille Chesnel, Gérard Amarenco, Samer Sheikh Ismael, Jacques Kerdraon, Frédérique Le Breton |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Sacrum Population Urinary Bladder Urology Bulbocavernosus reflex Physiology (medical) Sensation Medicine Humans In patient Prospective Studies education Aged education.field_of_study medicine.diagnostic_test Reflex Abnormal business.industry Upper motor neuron Cystometry Middle Aged Sensory Systems Pathophysiology Electric Stimulation Stimulus response Pudendal Nerve medicine.anatomical_structure Neurology Feasibility Studies Female Neurology (clinical) Nervous System Diseases business |
| Zdroj: | Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 132(9) |
| ISSN: | 1872-8952 |
| Popis: | Objective To analyze and quantify sacral spinal excitability through bulbocavernosus reflex (BCR) stimulus-response curves. Methods Thirty subjects with upper motor neuron lesions (UMN) and nine controls were included in this prospective, monocentric study. Sacral spinal excitability was assessed using stimulus-response curves of the BCR, modeled at different bladder filling volumes relative to the desire to void (as defined by the International Continence Society) during a cystometry. Variations in α (i.e. the slope of the stimulus-response curve) were considered as an indicator of the modulation of sacral spinal excitability. Results In all subjects, α increased during bladder filling suggesting the modulation of spinal sacral excitability during the filling phase. This increase was over 30% in 96.7% of neurological subjects and 88.9% of controls. The increase was higher before the first sensation to void in the neurological population (163.15%), compared to controls, (29.91%), p Conclusions We showed the possibility of using BCR stimulus-response curves to characterize sacral spinal response with an amplification of this response during bladder filling as well as a difference in this response amplification in patients with UMN in comparison with a control group. Significance BCR, through stimulus-response curves, might be an indicator of pelvic-perineal exaggerated reflex response and possibly a tool for evaluating treatment effectiveness. |
| Databáze: | OpenAIRE |
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