Design and synthesis of C-8 linked pyrrolobenzodiazepine-naphthalimide hybrids as anti-tumour agents
| Autor: | Ahmed Kamal, B. S. Narayan Reddy, G. Suresh Kumar Reddy, G. Ramesh |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Stereochemistry
Clinical Biochemistry Pharmaceutical Science Pyrrolobenzodiazepine Ether Antineoplastic Agents Naphthalenes Biochemistry Chemical synthesis Lethal Dose 50 chemistry.chemical_compound Benzodiazepines Structure-Activity Relationship Drug Discovery Tumor Cells Cultured Humans Pyrroles Imide Cytotoxicity Molecular Biology Organic Chemistry DNA In vitro chemistry Drug Design Lactam Molecular Medicine Drug Screening Assays Antitumor Linker |
| Zdroj: | Bioorganicmedicinal chemistry letters. 12(15) |
| ISSN: | 0960-894X |
| Popis: | The facile synthesis of C-8 linked pyrrolobenzodiazepine–naphthalimide hybrid analogues is described. The compounds are prepared with varying degrees of linker length in order to probe the structural requirements for optimal in vitro anti-tumour activity. Some of these new hybrid compounds showed higher cytotoxic activity than the existing natural and synthetic pyrrolo[2,1- c ][1,4]benzodiazepines. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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