COLORADO AGE-RELATED MACULAR DEGENERATION REGISTRY
| Autor: | Brandie D. Wagner, Alan G. Palestine, Jennifer L. Patnaik, Jeffrey L. Olson, Frank S Siringo, Paula E. Pecen, E Lacey Echalier, Stuart L. Fine, Marc T Mathias, Scott C N Oliver, Naresh Mandava, Anne M. Lynch, Jennifer N. Cathcart |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Colorado genetic structures Visual Acuity Logistic regression Cohort Studies 03 medical and health sciences 0302 clinical medicine Risk Factors Geographic Atrophy Internal medicine Odds Ratio Humans Medicine Registries 030212 general & internal medicine Family history Risk factor Aged Aged 80 and over business.industry General Medicine Odds ratio Middle Aged Macular degeneration medicine.disease eye diseases Confidence interval Ophthalmology Phenotype Research Design Multivariate Analysis Cohort Wet Macular Degeneration 030221 ophthalmology & optometry Female sense organs business Cohort study |
| Zdroj: | Retina. 39:656-663 |
| ISSN: | 0275-004X |
| Popis: | Purpose To study new and existing risk factors related to age-related macular degeneration (AMD) phenotypes in a Colorado cohort. Methods Age-related macular degeneration was categorized into early, intermediate, or advanced forms. Controls (n = 180) were patients with cataract and no AMD. Demographic and clinical data were gathered by patient interview and verified by chart review. Image data were reviewed by vitreoretinal specialists. Statistical analysis included univariable and multivariate logistic regression analysis (P Results Among the 456 patients with AMD, 157 (34.4%), 80 (17.6%), and 219 (48.0%) had the early/intermediate, geographic atrophy, and neovascular forms of the disease, respectively. Adjusted for age, African-American race was associated with a reduced risk of early/intermediate (adjusted odds ratio [AOR] = 0.08, confidence interval [CI] = 0.01-0.67) and neovascular AMD (AOR = 0.15, CI = 0.03-0.72). A family history of AMD was a risk factor for early/intermediate (AOR = 4.08, CI = 2.30-7.25), geographic atrophy (AOR = 8.62, CI = 3.77-19.7), and neovascular AMD (AOR = 3.76, CI = 2.16-6.56). A history of asthma was related to the early/intermediate form of AMD (AOR = 2.34, CI = 1.22-4.46). Conclusion Studying AMD in specific populations may reveal novel risk factors such as our finding of a relationship between asthma history and AMD. |
| Databáze: | OpenAIRE |
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