Survey of Hanganutziu and Deicher antibodies in operated patients
| Autor: | Yoshio Kitamura, Toshio Takeshima, Minetoshi Tomioka, Masaharu Naiki, Katsunori Nishida, Kaoru Matsumoto, Tomoko Higashihara, Mitsuaki Anzai, Kota Okinaga |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Liver Cirrhosis
Male Pathology medicine.medical_specialty Cirrhosis Esophageal Neoplasms Lymphoma Immunology Antibodies Heterophile Breast Neoplasms Enzyme-Linked Immunosorbent Assay Malignancy Antigen Antigens Neoplasm Cholelithiasis Stomach Neoplasms Neoplasms medicine Immunology and Allergy G(M3) Ganglioside Humans Stage (cooking) Aged Ganglioside biology business.industry Antibody titer Cancer General Medicine Middle Aged medicine.disease Pancreatic Neoplasms Colonic Neoplasms biology.protein Female Antibody business |
| Zdroj: | International archives of allergy and applied immunology. 95(2-3) |
| ISSN: | 0020-5915 |
| Popis: | The appearance of Hanganutziu and Deicher (HD) antibody in the sera of patients suffering from various diseases, including malignancies of some organs and liver disorders, was investigated by enzyme-linked immunosorbent assay using N-glycolylneuraminyl-lactosylceramide (HD3) and 4-O-acetyl-HD3 as the antigenic molecules. More than 25% of sera from patients suffering from malignancies, cholelithiasis and liver cirrhosis had HD antibody, whereas none of 41 sera from healthy persons had HD antibody. The percentage of HD antibody-positive patients was similar in stages I, II and III of gastric cancer and recurrence cases. Antibody titers of the positive patients in each stage were also not different from those in each other stage. These results indicated that HD antigenic expression on cancerous tissue is not dependent on the cancerous malignancy. The HD antibody level was elevated after surgical removal of cancerous tissues in 5 of 6 patients examined, indicating that tumor growth absorbed the serum antibody. Serum antibody against 4-O-acetyl-HD3 was detected independently of HD3 antibody in some cases; however, in most cases, correlation between the two antibody titers was observed. |
| Databáze: | OpenAIRE |
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