Human and Veterinary Vaccines for Lyme Disease
| Autor: | Richard T. Marconi, Andrew C. Camire, Amanda L. Hatke, Nathaniel S. O'Bier |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
0301 basic medicine
Veterinary medicine Disease Global Health Article 03 medical and health sciences Antigenic Diversity 0302 clinical medicine Lyme disease Animals Humans Medicine Borrelia burgdorferi Disease Reservoirs Lyme Disease Vaccines Zoonotic Infection biology business.industry Risk of infection Vaccination Lyme Disease Vaccines General Medicine medicine.disease biology.organism_classification Veterinary 030104 developmental biology Population Surveillance 030220 oncology & carcinogenesis Enzootic Disease Susceptibility business Human |
| Zdroj: | Current Issues in Molecular Biology Volume 42 Issue 1 Pages 191-222 Curr Issues Mol Biol |
| ISSN: | 1467-3037 |
| Popis: | Lyme disease (LD) is an emerging zoonotic infection that is increasing in incidence in North America, Europe, and Asia. With the development of safe and efficacious vaccines, LD can potentially be prevented. Vaccination offers a cost-effective and safe approach for decreasing the risk of infection. While LD vaccines have been widely used in veterinary medicine, they are not available as a preventive tool for humans. Central to the development of effective vaccines is an understanding of the enzootic cycle of LD, differential gene expression of Borrelia burgdorferi in response to environmental variables, and the genetic and antigenic diversity of the unique bacteria that cause this debilitating disease. Here we review these areas as they pertain to past and present efforts to develop human, veterinary, and reservoir targeting LD vaccines. In addition, we offer a brief overview of additional preventative measures that should employed in conjunction with vaccination. |
| Databáze: | OpenAIRE |
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