Effects of Intrathecal Verapamil on Cerebral Vasospasm in Experimental Rat Study

Autor: Ersin Karataş, Mustafa Yasin Sağlam, Salim Katar, Enes Akkaya, Abdurrahim Kocyigit, Fatih Çalış, Hakan Hanimoglu, Mustafa Aziz Hatiboglu, Sevket Evran, Mehmet Hakan Seyithanoglu, Mehmet Yasar Kaynar, Serdar Çevik
Přispěvatelé: SEYİTHANOĞLU, MEHMET HAKAN, İstinye Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Anestezi Bölümü, Cevik, Serdar
Rok vydání: 2019
Předmět:
Male
Subarachnoid hemorrhage
Vasodilator Agents
Nicardipine
Apoptosis
Vasodilation
Neuroprotection
Rats
Sprague-Dawley
03 medical and health sciences
0302 clinical medicine
Cerebral vasospasm
medicine
Animals
Vasospasm
Intracranial
cardiovascular diseases
Intrathecal Verapamil
Nimodipine
Injections
Spinal
Endothelin-1
business.industry
Akkaya E.
Evran S.
Calis F.
Cevik S.
Hanimoglu H.
SEYİTHANOĞLU M. H.
Katar S.
Karatas E.
KOÇYİĞİT A.
Saglam M. Y.
et al.
-Effects of Intrathecai Verapamil on Cerebral Vasospasm in Experimental Rat Study-
WORLD NEUROSURGERY
cilt.127
2019
Vasospasm
Subarachnoid Hemorrhage
Calcium Channel Blockers
medicine.disease
Aneurysm
Rats
Oxidative Stress
Treatment Outcome
Verapamil
030220 oncology & carcinogenesis
Anesthesia
cardiovascular system
Surgery
Neurology (clinical)
business
030217 neurology & neurosurgery
medicine.drug
Zdroj: World Neurosurgery. 127:e1104-e1111
ISSN: 1878-8750
Popis: 16th World Congress of Neurosurgery of the World-Federation-of-Neurosurgical-Societies (WFNS) -- AUG 20-25, 2017 -- Istanbul, TURKEY BACKGROUND: Verapamil a calcinarn channel blacker, has shown promising results on cerebral vasospasm. However, it has not yet been accepted for treatment or prevention purposes because of the associated side effects, Although the effective results of nimodipine and nicardipine's intrathecal administration are well known, intrathecal verapamil has not been considered earlier. We used an experimental subarachnoid hemorrhage induced vasospasm model for the evaluation of vasodilator and neuroprotective effects of intrathecal verapamil, METHODS: A total of 24 Sprague-Davvley rats were randomly divided into the following 3 groups: group 1 (sham), group 2 (subarachnoid hemorrhage), and group 3 {verapamil). A double hemorrhage method was used. Group 2 did not receive any treatment. Verapamil (Eporon, Hem Ilac, Turkey) at a dose of 1000 mu g/kg was given intrathecally to group 3 rats. The animals were euthanized on day 7 of the procedure. Arterial wall thickness and lumen diameter in the basilar arterial cross-sectional areas, endothelin-1 serum level, oxidative stress index, and apoptosis were measured in all groups. RESULTS: In the verapamil group, wall thickness, endothelin-1 level, oxidative stress index, and apoptosis were found to be significantly lower than the subarachnoid hemorrhage group, but the lumen diameter was found to be greater, Intrathecal verapamil was found to decrease vasospasm parameters and apoptosis and increase the antioxidant and antiapoptotic pathways. CONCLUSIONS: Our findings suggest that intrathecal verapamil can prevent vasospasnt oxidative stress, and apoptosis after experimental subarachnoid hemorrhage. World Federat Neurosurg Soc Bezmialem Vakif University FundBezmialem Vakif University [3.2015/40] This work was supported by the Bezmialem Vakif University Fund (Project Number: 3.2015/40). WOS:000473128300136 30980985 Q3
Databáze: OpenAIRE
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