Clinical and prognostic 18F-FDG PET/CT role in recurrent vulvar cancer: a multicentric experience
| Autor: | Francesco Bertagna, Domenico Albano, Luigi Gianolli, Paola Ferro, Elena Busnardo, Mattia Bonacina, Luca Camoni, Raffaele Giubbini, Giordano Savelli |
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| Rok vydání: | 2021 |
| Předmět: |
Chemotherapy
medicine.medical_specialty business.industry medicine.medical_treatment Vulvar cancer medicine.disease Predictive value 030218 nuclear medicine & medical imaging Radiation therapy 03 medical and health sciences 0302 clinical medicine True negative 030220 oncology & carcinogenesis medicine Radiology Nuclear Medicine and imaging Fdg pet ct Progression-free survival Radiology business Recurrent Vulvar Cancer |
| Zdroj: | Japanese Journal of Radiology. 40:66-74 |
| ISSN: | 1867-108X 1867-1071 |
| DOI: | 10.1007/s11604-021-01173-x |
| Popis: | Purpose The aim of this retrospective multicentric study was to investigate the diagnostic performance, the prognostic value and the impact of 18F-FDG PET/CT on treatment decision-making in patients with suspected recurrent vulvar cancer (VC). Materials and methods Sixty-three patients affected by VC performed 18F-FDG-PET/CT for restaging purposes in case of suspected clinical and/or radiological recurrence. Histopatology results if available and/or clinical-imaging follow-up for at least 12 months were considered as reference standard. The diagnostic accuracy and the clinical impact of 18F-FDG PET/CT were investigated. Progression free survival (PFS) and overall survival (OS) were calculated using Kaplan–Meier curves. Results Fifty-two (82.5%) PET/CT showed the presence of recurrence, while the remaining 11 (17.5%) were negative. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy of PET/CT were 100% (95%CI 93–100%), 92% (95%CI 62–100%), 98% (95%CI 89–99%), 100% and 98% (95%CI 92–100%). A relevant impact of 18F-FDG PET/CT imaging was registered in 28 cases: in 12 cases moving from local therapy to chemotherapy due to the recognition of disseminate localizations; in 10 showing the site of recurrence in presence of negative conventional imaging, and in 6 cases confirming to be true negative and avoiding unnecessary therapies. Beside advanced age and HPV status, a positive restaging 18F-FDG PET/CT scan was significantly correlated with shorter PFS and OS compared to negative scan (p Conclusions 18F-FDG PET/CT demonstrated to be an accurate tool in the assessing of recurrent VC with high sensitivity and specificity and with a significant impact on clinical decision-making. Restaging 18F-FDG PET/CT findings were associated with survival. |
| Databáze: | OpenAIRE |
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