Alleviation of dry mouth by saliva substitutes improved swallowing ability and clinical nutritional status of post-radiotherapy head and neck cancer patients: a randomized controlled trial
| Autor: | Dunyaporn Trachootham, Sineepat Talungchit, Aroonwan Lam-ubol, Orapin Chokchaitam, Tippawan Pongcharoen, Wannaporn Paemuang, On ong Mungkung, Sumalee Nuchit |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Saliva Nutritional Status Xerostomia law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial Swallowing stomatognathic system law Saliva substitute Internal medicine Medicine Humans Single-Blind Method Head and neck cancer business.industry Saliva Artificial Nutritional status 030206 dentistry Dysphagia Middle Aged medicine.disease Dry mouth Deglutition Radiation therapy Treatment Outcome Oncology Head and Neck Neoplasms 030220 oncology & carcinogenesis Original Article Female medicine.symptom business |
| Zdroj: | Supportive Care in Cancer |
| ISSN: | 1433-7339 0941-4355 |
| Popis: | Purpose The aim of this study is to investigate the effect of an edible saliva substitute, oral moisturizing jelly (OMJ), and a topical saliva gel (GC) on dry mouth, swallowing ability, and nutritional status in post-radiotherapy head and neck cancer patients. Methods Sixty-two post-radiation head and neck cancer patients with xerostomia completed a blinded randomized controlled trial. They were advised to swallow OMJ (n = 31) or apply GC orally (n = 31) for 2 months. Outcome measures were assessed at baseline, 1, and 2 months, including subjective and objective dry mouth (Challcombe) scores, subjective swallowing problem scores (EAT-10), water swallowing time, clinical nutritional status (PG-SGA), body weight, and dietary intake. Results After 1 and 2 months of interventions, subjective and objective dry mouth scores, subjective swallowing problem scores, swallowing times, and clinical nutritional status in both groups were significantly improved (p < 0.0001). Compared to GC, OMJ group had higher percent improvement in all outcome measures (p < 0.001) except swallowing time and clinical nutritional status. Interestingly, subjective dry mouth scores were significantly correlated with subjective swallowing problem scores (r = 0.5321, p < 0.0001). Conclusions Continuous uses of saliva substitutes (OMJ or GC) for at least a month improved signs and symptoms of dry mouth and enhanced swallowing ability. An edible saliva substitute was superior to a topical saliva gel for alleviating dry mouth and swallow problems. These lead to improved clinical nutritional status. Thus, palliation of dry mouth may be critical to support nutrition of post-radiotherapy head and neck cancer patients. Clinical trial registry Clinicaltrials.gov NCT03035825 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink