Current Scenario of 1,3-oxazole Derivatives for Anticancer Activity
| Autor: | Jing Wen, Xinjia Yan, Zhi Xu, Lei Fan, Xiaobo Wang, Lin Zhou |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Molecular Structure
Cell Survival 010405 organic chemistry business.industry Antineoplastic Agents General Medicine Bioinformatics 01 natural sciences 0104 chemical sciences Structure-Activity Relationship 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry Drug Discovery Humans Medicine Drug Screening Assays Antitumor Cancer cell lines business Oxazoles Cell Proliferation Oxazole |
| Zdroj: | Current Topics in Medicinal Chemistry. 20:1916-1937 |
| ISSN: | 1568-0266 |
| DOI: | 10.2174/1568026620666200624161151 |
| Popis: | Cancer, which has been cursed for human beings for long time is considered as one of the leading causes of morbidity and mortality across the world. In spite of different types of treatments available, chemotherapy is still deemed as a favored treatment for the cancer. Unfortunately, many currently accessible anticancer agents have developed multidrug resistance along with fatal adverse effects. Therefore, intensive efforts have been made to seek for new active drugs with improved anticancer efficacy and reduced adverse effects. In recent years, the emergence of heterocyclic ring-containing anticancer agents has gained a great deal of attention among medicinal chemists. 1,3- oxazole is a versatile heterocyclic compound, and its derivatives possess broad-spectrum pharmacological properties, including anticancer activity against both drug-susceptible, drug-resistant and even multidrug-resistant cancer cell lines through multiple mechanisms. Thus, the 1,3-oxazole moiety is a useful template for the development of novel anticancer agents. This review will provide a comprehensive overview of the recent advances on 1,3-oxazole derivatives with potential therapeutic applications as anticancer agents, focus on the chemical structures, anticancer activity, and mechanisms of action. |
| Databáze: | OpenAIRE |
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