A Randomized Controlled Trial of Fasting and Lifestyle Modification in Patients with Metabolic Syndrome: Effects on Patient-Reported Outcomes
| Autor: | Jeitler, Michael, Lauche, Romy, Hohmann, Christoph, Choi, Kyung-Eun (Anna), Schneider, Nadia, Steckhan, Nico, Rathjens, Florian, Anheyer, Dennis, Paul, Anna, von Scheidt, Christel, Ostermann, Thomas, Schneider, Elisabeth, Koppold-Liebscher, Daniela, Kessler, Christian S., Dobos, Gustav, Michalsen, Andreas, Cramer, Holger |
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| Rok vydání: | 2022 |
| Předmět: |
Male
Metabolic Syndrome lifestyle mindfulness Depression Medizin MICOM (Mind-Body Medicine in Integrative and Complementary Medicine) modified DASH diet Fasting relaxation Mediterranean diet Quality of Life Humans Female Patient Reported Outcome Measures self-efficacy Life Style 600 Technik Medizin angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit |
| Zdroj: | Nutrients. 14(17) |
| ISSN: | 2072-6643 |
| Popis: | CA extern Lifestyle interventions can have a positive impact on quality of life and psychological parameters in patients with metabolic syndrome (MetS). In this randomized controlled trial, 145 participants with MetS (62.8% women; 59.7 +/- 9.3 years) were randomized to (1) 5-day fasting followed by 10 weeks of lifestyle modification (F + LM; modified DASH diet, exercise, mindfulness; n = 73) or (2) 10 weeks of lifestyle modification only (LM; n = 72). Outcomes were assessed at weeks 0, 1, 12, and 24, and included quality of life (Short-Form 36 Health Survey Questionnaire, SF-36), anxiety/depression (Hospital Anxiety and Depression Scale, HADS), stress (Cohen Perceived Stress Scale, CPSS), mood (Profile of Mood States, POMS), self-efficacy (General Self-Efficacy Scale, GSE), mindfulness (Mindfulness Attention Awareness Scale, MAAS), and self-compassion (Self-Compassion Scale, SCS). At week 1, POMS depression and fatigue scores were significantly lower in F + LM compared to LM. At week 12, most self-report outcomes improved in both groups-only POMS vigor was significantly higher in F + LM than in LM. Most of the beneficial effects within the groups persisted at week 24. Fasting can induce mood-modulating effects in the short term. LM induced several positive effects on quality of life and psychological parameters in patients with MetS. |
| Databáze: | OpenAIRE |
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