Erythrocyte membrane coated nanoparticle-based control releasing hydrogen sulfide system protects ischemic myocardium
| Autor: | Shuyan Wen, Liewen Pang, Wenshuo Wang, Yiqing Wang, Jiechun Huang, Xiaotian Sun, Jing-E Zhou, Kai Huang, Fangrui Wang |
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| Rok vydání: | 2021 |
| Předmět: |
Biocompatibility
Biomedical Engineering Medicine (miscellaneous) Bioengineering Myocardial Reperfusion Injury 02 engineering and technology Development Pharmacology 03 medical and health sciences chemistry.chemical_compound In vivo medicine Humans General Materials Science Hydrogen Sulfide Cytotoxicity 030304 developmental biology 0303 health sciences Myocardium Erythrocyte Membrane Hypoxia (medical) 021001 nanoscience & nanotechnology Red blood cell Diallyl trisulfide medicine.anatomical_structure chemistry Circulatory system Nanoparticles medicine.symptom 0210 nano-technology Iron oxide nanoparticles |
| Zdroj: | Nanomedicine (London, England). 16(6) |
| ISSN: | 1748-6963 |
| Popis: | Aim: To construct a long circulatory and sustained releasing H2S system and explore its protective effects on myocardial ischemia and reperfusion (I/R) injury. Materials & methods: Red blood cell (RBC) membrane-coated, diallyl trisulfide (DATS)-carrying mesoporous iron oxide nanoparticles (MIONs) (RBC-DATS-MIONs) were prepared and characterized. Cytotoxicity and cellular uptake were studied in vitro, followed by in vivo assessment of safety, distribution and effect on cardiac function following I/R injury. Results: RBC-DATS-MIONs exhibited excellent biocompatibility, extended circulatory time and controlled-release of H2S in plasma and myocardium. They exhibited superior therapeutic effects on in vitro hypoxia/reoxygenation models and in vivo myocardial I/R models, which involved various mechanisms, including anti-apoptosis, anti-inflammatory and antioxidant activities. Conclusion: This work provides a new potential platform for best utilizing the protective effects of H2S by prolonging its releasing process. |
| Databáze: | OpenAIRE |
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