A biocatalytic cascade for the conversion of fatty acids to fatty amines
| Autor: | Han Bevinakatti, Nicholas J. Turner, James L. Galman, Sasha R. Derrington, Joan Citoler |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Carbon chain
Reaction conditions Fatty amine Carboxylic acid reductase 010405 organic chemistry Chemistry 010402 general chemistry 01 natural sciences 7. Clean energy Pollution 0104 chemical sciences Transaminase chemistry.chemical_compound Environmental Chemistry Organic chemistry Metal catalyst Selectivity Amination |
| Zdroj: | Green Chemistry |
| ISSN: | 1463-9262 |
| DOI: | 10.1039/c9gc02260k |
| Popis: | Fatty amine synthesis from renewable sources is an energetically-demanding process involving toxic metal catalysts and harsh reaction conditions as well as selectivity problems. Herein we present a mild, biocatalytic alternative to the conventional amination of fatty acids through a one-pot tandem cascade performed by a carboxylic acid reductase (CAR) and a transaminase (ω-TA). Saturated and unsaturated fatty acids, with carbon chain lengths ranging from C6 to C18, were successfully aminated obtaining conversions of up to 96%. |
| Databáze: | OpenAIRE |
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