Drosophila as a Model to Study Brain Innate Immunity in Health and Disease
| Autor: | Stanislava Chtarbanova, Shu Hui Lye |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
autophagy animal diseases Central nervous system Disease Review Biology Catalysis Inorganic Chemistry lcsh:Chemistry 03 medical and health sciences 0302 clinical medicine Immune system medicine Physical and Theoretical Chemistry Molecular Biology innate immunity lcsh:QH301-705.5 Spectroscopy Innate immune system Organic Chemistry Neurodegeneration fungi neurodegeneration phagocytosis General Medicine biochemical phenomena metabolism and nutrition medicine.disease biology.organism_classification Acquired immune system Computer Science Applications 030104 developmental biology medicine.anatomical_structure Drosophila lcsh:Biology (General) lcsh:QD1-999 inflammaging brain infection Drosophila melanogaster Neuroscience Neural development 030217 neurology & neurosurgery |
| Zdroj: | International Journal of Molecular Sciences, Vol 19, Iss 12, p 3922 (2018) International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| Popis: | Innate immunity is the first line of defense against invading pathogens and plays an essential role in defending the brain against infection, injury, and disease. It is currently well recognized that central nervous system (CNS) infections can result in long-lasting neurological sequelae and that innate immune and inflammatory reactions are highly implicated in the pathogenesis of neurodegeneration. Due to the conservation of the mechanisms that govern neural development and innate immune activation from flies to mammals, the lack of a classical adaptive immune system and the availability of numerous genetic and genomic tools, the fruit fly Drosophila melanogaster presents opportunities to investigate the cellular and molecular mechanisms associated with immune function in brain tissue and how they relate to infection, injury and neurodegenerative diseases. Here, we present an overview of currently identified innate immune mechanisms specific to the adult Drosophila brain. |
| Databáze: | OpenAIRE |
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