Role of Multiple Comorbidities and Therapies in Conditioning the Clinical Severity of DRESS: A Mono-Center Retrospective Study of 25 Cases

Autor: Emanuela Bonoldi, Andrea Toniato, Joseph Scibilia, Marta Piantanida, Scarlett Valeria Bernal Ortiz, Michele Nichelatti, Eleonora Brusamolino, Chiara Gamba, Linda Borgonovo, Valentina S. Caputo, Jan Walter Schroeder, Elide A. Pastorello, Valeria Fabbri, Luca Giuseppe Balossi
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Male
severity
Disease
Comorbidity
Severity of Illness Index
Drug reaction with eosinophilia and systemic symptoms
drug-induced hypersensitivity syndrome
030207 dermatology & venereal diseases
0302 clinical medicine
Retrospective analysis
Eosinophilia
risk factors
Clinical severity
Biology (General)
Spectroscopy
General Medicine
Computer Science Applications
Chemistry
Drug Hypersensitivity Syndrome
Female
medicine.symptom
medicine.drug
medicine.medical_specialty
QH301-705.5
Allopurinol
macromolecular substances
comorbidities
Skin Diseases
Catalysis
Article
Inorganic Chemistry
03 medical and health sciences
Internal medicine
medicine
drug reaction with eosinophilia and systemic symptoms
Humans
Drug reaction
Physical and Theoretical Chemistry
Molecular Biology
QD1-999
DRESS syndrome
Aged
Retrospective Studies
business.industry
Organic Chemistry
Retrospective cohort study
medicine.disease
SCAR
030228 respiratory system
business
Zdroj: International Journal of Molecular Sciences, Vol 22, Iss 7072, p 7072 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 13
ISSN: 1661-6596
1422-0067
Popis: DRESS/DiHS is a complex and potentially fatal drug reaction. Little is known about risk factors and elements that can help to identify patients with a severe reaction early. The aim of the study was to investigate those factors favoring the disease and its severity by analyzing the clinical conditions and therapies preceding the reaction. We conducted a retrospective analysis on patients admitted to our center between 2010 and 2020 who were discharged with a diagnosis of DRESS. We used the RegiSCAR diagnostic criteria. We defined the severity of DRESS using the criteria of Mizukawa et al. We included 25 patients (15 females) with a median age of 66 years. Skin involvement, eosinophilia, and liver injury were the most important aspects. Allopurinol was found to be the most involved drug. Reaction severity was significantly associated with the number of daily medications (p = 0.0067) and an age of at least 68 years (p = 0.013). In addition, 75% of severe cases had at least three comorbidities in history, and most of the severe cases were female. In our study the advanced age, the high number of comorbidities and home therapies, and the inflammatory state were found to be predisposing elements to the development of the disease and its severity.
Databáze: OpenAIRE
Externí odkaz: