Altered Expression of PRKX, WNT3 and WNT16 in Human Nodular Basal Cell Carcinoma

Autor:	Simone Karst Passos, Robert Pogue, Natalia Gurgel Do Carmo, Maria Sueli Soares Felipe, Cintia do Couto Mascarenhas, Luis Henrique Toshihiro Sakamoto, Rosângela Vieira de Andrade
Rok vydání:	2016
Předmět:	Male Cancer Research animal structures Skin Neoplasms Nodular basal cell carcinoma Biology Protein Serine-Threonine Kinases Real-Time Polymerase Chain Reaction law.invention Wnt3 Protein 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine law medicine Cluster Analysis Humans Basal cell carcinoma skin and connective tissue diseases Gene Hedgehog Polymerase chain reaction Aged Cell Proliferation Skin Aged 80 and over integumentary system Gene Expression Profiling fungi Wnt signaling pathway General Medicine Middle Aged medicine.disease Phenotype Up-Regulation Gene Expression Regulation Neoplastic Wnt Proteins Oncology Carcinoma Basal Cell 030220 oncology & carcinogenesis Cancer research Female Signal transduction Signal Transduction
Zdroj:	Anticancer research. 36(9)
ISSN:	1791-7530
Popis:	BACKGROUND/AIM Nodular and superficial are the most common subtypes of basal cell carcinoma (BCC). Signaling pathways such as Hedgehog (HH) and Wingless (WNT) signaling are associated with BCC phenotypic variation. The aim of the study was to evaluate of the expression profiles of 84 genes related to the WNT and HH signaling pathways in patients with nodular and superficial BCC. MATERIALS AND METHODS A total of 58 BCCs and 13 samples of normal skin were evaluated by quantitative real-time polymerase chain reaction (qPCR) to detect the gene-expression profile. RESULTS qPCR array showed segregation in BCC subtypes compared to healthy skin. PRKX, WNT3 and WNT16 were significantly (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aee5bb9d7f5a768474856b0282704095 https://pubmed.ncbi.nlm.nih.gov/27630294 Zobrazit plný text záznamu