Cardiac Leiomyosarcoma in a Cat Presenting for Bilateral Renal Neoplasia
| Autor: | D.K. Richard, Debra A. Tokarz, J. Allen, E. Luckring, M.E. Schreeg, Elizabeth Thompson, M.C. Lewis, M. Evola, K. Piner, B.J. Evans, Darcy B. Adin |
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| Rok vydání: | 2019 |
| Předmět: |
Leiomyosarcoma
Pathology medicine.medical_specialty 040301 veterinary sciences Population Infarction Cat Diseases 030308 mycology & parasitology Pathology and Forensic Medicine Heart Neoplasms 0403 veterinary science Lesion 03 medical and health sciences Cytology medicine Animals Cardiac Leiomyosarcoma education 0303 health sciences Multiple Pulmonary Nodules education.field_of_study General Veterinary business.industry 04 agricultural and veterinary sciences medicine.disease Kidney Neoplasms Cats Female Sarcoma medicine.symptom business |
| Zdroj: | Journal of Comparative Pathology. 168:19-24 |
| ISSN: | 0021-9975 |
| DOI: | 10.1016/j.jcpa.2019.02.005 |
| Popis: | A 10-year-old neutered female domestic longhair cat was presented to a tertiary care veterinary hospital for evaluation of a right renal mass that was identified incidentally on abdominal radiographs and classified further as a sarcoma based on fine needle aspiration cytology. Further diagnostic workup, including ultrasound and cytology, identified a sarcoma in the left kidney. After approximately 1 month of conservative medical management, the clinical condition deteriorated and the cat was humanely destroyed. Post-mortem examination confirmed bilateral renal masses with multifocal infarction and extensive necrosis, and further identified a large mass at the apex of the heart as well as multiple pulmonary nodules. Microscopical examination of the masses identified a population of poorly-differentiated neoplastic spindle cells, consistent with sarcoma. Immunohistochemically, the neoplastic cells expressed smooth muscle actin and muscle-specific actin, but were negative for myoglobin and factor VIII. Phosphotungstic acid-haematoxylin staining was unable to identify cross-striations in the neoplastic cells. Based on these results and the pattern of lesion distribution, the cat was diagnosed with cardiac leiomyosarcoma with pulmonary and bilateral renal metastasis. |
| Databáze: | OpenAIRE |
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