Duplication and triplication of der(21)t(8;21)(q22;q22) in acute myeloid leukemia
| Autor: | Amanda LeBlanc, Michael Mikulasovich, Angela Scalise, Deepa Manwani, Vesna Najfeld, Alla Keyzner |
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| Rok vydání: | 2009 |
| Předmět: |
Cancer Research
Adolescent Oncogene Proteins Fusion Chromosomes Human Pair 21 Isochromosome Population Biology Bioinformatics Translocation Genetic RUNX1 Translocation Partner 1 Protein Text mining Proto-Oncogene Proteins Gene duplication Genetics Humans education Molecular Biology In Situ Hybridization Fluorescence education.field_of_study business.industry Remission Induction Myeloid leukemia Middle Aged Isochromosomes Leukemia Myeloid Acute Karyotyping Core Binding Factor Alpha 2 Subunit Female T(8 21)(q22 q22) business Chromosomes Human Pair 8 Transcription Factors |
| Zdroj: | Cancer Genetics and Cytogenetics. 188:83-87 |
| ISSN: | 0165-4608 |
| DOI: | 10.1016/j.cancergencyto.2008.10.004 |
| Popis: | We report on two patients with complicons resulting in duplication der(21)t(8;21)(q22;q22), triplication in the form of isochromosome of der(21)t(8;21), and four copies of ETO-AML1 fusion. Duplication of der(21) was present at diagnosis as a minor cell population in one patient, while the presence of isoderivative (21)t(8;21) characterized the relapse cells of the second patient. Due to the rarity of these cases, literature search of other reported cases of complicons may be taken as evidence that duplication and triplication of ETO-AML1 may be a poor prognostic indicator, regardless of whether it is present at diagnosis or relapse. |
| Databáze: | OpenAIRE |
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