From Glucose to Polymers: A Continuous Chemoenzymatic Process
| Autor: | John Zientko, Sampa Maiti, Reuben T. Bettinger, Jun Wang, Saikat Manna, Nicholas Banahene, Yi Xu, Wenjun Du, Aaron P. Esser-Kahn, Lucynda Pham, Zhijie Liang |
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| Rok vydání: | 2020 |
| Předmět: |
Green chemistry
chemistry.chemical_classification 010405 organic chemistry General Chemistry Polymer General Medicine 010402 general chemistry 01 natural sciences Combinatorial chemistry Catalysis 0104 chemical sciences chemistry.chemical_compound Monomer chemistry Scientific method Yield (chemistry) Orthoester Reaction system |
| Zdroj: | Angewandte Chemie. 132:19105-19109 |
| ISSN: | 1521-3757 0044-8249 |
| DOI: | 10.1002/ange.202006468 |
| Popis: | Efforts to synthesize degradable polymers from renewable resources are deterred by technical and economic challenges; especially, the conversion of natural building blocks into polymerizable monomers is inefficient, requiring multistep synthesis and chromatographic purification. Herein we report a chemoenzymatic process to address these challenges. An enzymatic reaction system was designed that allows for regioselective functional group transformation, efficiently converting glucose into a polymerizable monomer in quantitative yield, thus removing the need for chromatographic purification. With this key success, we further designed a continuous, three-step process, which enabled the synthesis of a sugar polymer, sugar poly(orthoester), directly from glucose in high yield (73 % from glucose). This work may provide a proof-of-concept in developing technically and economically viable approaches to address the many issues associated with current petroleum-based polymers. |
| Databáze: | OpenAIRE |
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