Neuroprotective effects of tetrandrine against vascular dementia
| Autor: | Baixue Wu, Guangcheng Qin, Lianlian Chen, Jiying Zhou, Yan-ling Lv, Ze-zhi Wu, Bei Gui, Lixue Chen |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
interleukin-1β Morris water navigation task Pharmacology tetrandrine Neuroprotection lcsh:RC346-429 N-methyl-D-aspartate receptor 2B phosphorylation at tyrosine 1472 Stephania tetrandra 03 medical and health sciences symbols.namesake chemistry.chemical_compound 0302 clinical medicine Developmental Neuroscience neuronal necrosis Medicine Hippocampus (mythology) nerve regeneration Receptor Vascular dementia lcsh:Neurology. Diseases of the nervous system biology business.industry vascular dementia biology.organism_classification medicine.disease ischemic cerebrovascular disease N-methyl-D-aspartic acid receptor 2B neural regeneration Tetrandrine 030104 developmental biology chemistry Nissl body symbols business Neuroscience 030217 neurology & neurosurgery Research Article |
| Zdroj: | Neural Regeneration Research, Vol 11, Iss 3, Pp 454-459 (2016) Neural Regeneration Research |
| ISSN: | 1673-5374 |
| DOI: | 10.4103/1673-5374.179058 |
| Popis: | Tetrandrine is one of the major active ingredients in Menispermaceae Stephania tetrandra S. Moore, and has specific therapeutic effects in ischemic cerebrovascular disease. Its use in vascular dementia has not been studied fully. Here, we investigated whether tetrandrine would improve behavioral and cellular impairments in a two-vessel occlusion rat model of chronic vascular dementia. Eight weeks after model establishment, rats were injected intraperitoneally with 10 or 30 mg/kg tetrandrine every other day for 4 weeks. Behavioral assessment in the Morris water maze showed that model rats had longer escape latencies in training trials, and spent less time swimming in the target quadrant in probe trials, than sham-operated rats. However, rats that had received tetrandrine showed shorter escape latencies and longer target quadrant swimming time than untreated model rats. Hematoxylin-eosin and Nissl staining revealed less neuronal necrosis and pathological damage, and more living cells, in the hippocampus of rats treated with tetrandrine than in untreated model rats. Western blot assay showed that interleukin-1β expression, and phosphorylation of the N-methyl-D-aspartate 2B receptor at tyrosine 1472, were lower in model rats that received tetrandrine than in those that did not. The present findings suggest that tetrandrine may be neuroprotective in chronic vascular dementia by reducing interleukin-1β expression, N-methyl-D-aspartate receptor 2B phosphorylation at tyrosine 1472, and neuronal necrosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|