Modelling the role of redox-related mechanisms in musculoskeletal ageing
| Autor: | Daryl P. Shanley, Carole J. Proctor, Alvaro Martinez Guimera |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Aging Computer science Musculoskeletal Physiological Phenomena Cellular level medicine.disease_cause Biochemistry Redox 03 medical and health sciences 0302 clinical medicine Physiology (medical) medicine Animals Humans Computer Simulation Inflammation Oxidative Stress 030104 developmental biology Ageing Reactive Oxygen Species Oxidation-Reduction Neuroscience Signalling pathways 030217 neurology & neurosurgery Oxidative stress Signal Transduction |
| Zdroj: | Free Radical Biology and Medicine. 132:11-18 |
| ISSN: | 0891-5849 |
| DOI: | 10.1016/j.freeradbiomed.2018.09.013 |
| Popis: | The decline in the musculoskeletal system with age is driven at the cellular level by random molecular damage. Cells possess mechanisms to repair or remove damage and many of the pathways involved in this response are regulated by redox signals. However, with ageing there is an increase in oxidative stress which can lead to chronic inflammation and disruption of redox signalling pathways. The complexity of the processes involved has led to the use of computational modelling to help increase our understanding of the system, test hypotheses and make testable predictions. This paper will give a brief background of the biological systems that have been modelled, an introduction to computational modelling, a review of models that involve redox-related mechanisms that are applicable to musculoskeletal ageing, and finally a discussion of the future potential for modelling in this field. |
| Databáze: | OpenAIRE |
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