Antibacterial screening of Rumex species native to the Carpathian Basin and bioactivity-guided isolation of compounds from Rumex aquaticus
| Autor: | Orsolya Orbán-Gyapai, Andrea Vasas, Erika Liktor-Busa, Edit Urbán, Norbert Kúsz, Dóra Stefkó, Judit Hohmann |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Microbial Sensitivity Tests Naphthalenes 01 natural sciences Polygonaceae 03 medical and health sciences chemistry.chemical_compound Glucoside Staphylococcus epidermidis Drug Discovery Botany Rumex Piceid Pharmacology Plants Medicinal Citreorosein biology Plant Extracts General Medicine biology.organism_classification Anti-Bacterial Agents 0104 chemical sciences 010404 medicinal & biomolecular chemistry 030104 developmental biology chemistry Emodin Antibacterial activity |
| Zdroj: | Fitoterapia. 118:101-106 |
| ISSN: | 0367-326X |
| DOI: | 10.1016/j.fitote.2017.03.009 |
| Popis: | Plants belonging to the genus Rumex (family Polygonaceae) are used worldwide in traditional medicine for the treatment of various diseases caused by different microorganisms (e.g. bacteria-related dermatologic conditions, dysentery and enteritis). The present study focused on the antibacterial screening of Rumex species native to the Carpathian Basin, and isolation of compounds from one of the most efficient species, Rumex aquaticus. The antibacterial effects of n-hexane, chloroform and aqueous fractions of methanol extracts prepared from different parts of 14 Rumex species (R. acetosella, R. acetosa, R. alpinus, R. aquaticus, R. conglomeratus, R. crispus, R. hydrolapathum, R. obtusifolius subsp. obtusifolius, R. obtusifolius subsp. subalpinus, R. patientia, R. pulcher, R. scutatus, R. stenophyllus and R. thyrsiflorus) were investigated against Staphylococcus epidermidis, S. aureus, MRSA, Bacillus subtilis, Moraxella catarrhalis, Streptococcus pyogenes, S. pneumoniae, S. agalactiae, Pseudomonas aeruginosa, Escherichia coli and Klebsiella pneumoniae using the disc diffusion method. Mainly the n-hexane and chloroform extracts prepared from the roots of the plants displayed high antibacterial activity (inhibition zones > 15 mm) against one or more bacterial strains. The highly active extracts of the aerial part and root of R. aquaticus were subjected to a multistep separation procedure. 19 Compounds, among them naphthalenes (musizin, and its glucoside, torachrysone-glucoside, 2-methoxystypandrone), anthraquinones (emodin, chrysophanol, physcion, citreorosein, chrysophanol-8-O-glucoside), flavonoids (quercetin, quercetin-3,3′-dimethylether, isokaempferide, quercetin 3-O-arabinoside, quercetin 3-O-galactoside, catechin), stilbenes (resveratrol, piceid), and 1-stearoylglycerol were isolated from the plant. The antibacterial activities of isolated compounds were determined, and it was observed that especially naphthalenes exerted remarkable antibacterial effects against several bacterial strains. |
| Databáze: | OpenAIRE |
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