Prostate-specific antigen and new related markers for prostate cancer
| Autor: | Rose T. Daher, Mona Beaini |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
PCA3
Male Clinical Biochemistry urologic and male genital diseases Malignancy Sensitivity and Specificity Specimen Handling Management of prostate cancer Prostate cancer Antigen Prostate medicine Humans Prostatectomy business.industry Reverse Transcriptase Polymerase Chain Reaction Biochemistry (medical) Prostatic Neoplasms General Medicine Kallikrein Middle Aged Prostate-Specific Antigen medicine.disease Prostate-specific antigen medicine.anatomical_structure Immunology Cancer research Female Kallikreins business Tissue Kallikreins |
| Zdroj: | Clinical chemistry and laboratory medicine. 36(9) |
| ISSN: | 1434-6621 |
| Popis: | Although prostate-specific antigen (PSA), or human kallikrein 3, is the most valuable tool available for the diagnosis and management of prostate cancer, as currently used it is insufficiently sensitive and specific for early detection or staging of the malignancy. Many new concepts have been introduced in order to optimize the clinical use of PSA measurements, but each one has its own drawbacks. The molecular forms of PSA, especially the free PSA, seem to be useful for the detection of prostate cancer in men with PSA concentrations falling in the 4–10 μg/l range. New molecular techniques, such as reverse transcriptase polymerase chain reaction for the detection of minimal amounts of PSA messenger RNA and prostate-specific membrane antigen, offer new promise for the prognosis and possibly staging of prostate cancer. On the other hand, human kallikrein 2, a serine protease closely related to PSA that is also expressed predominantly in the prostate, may be a new adjuvant marker for prostate cancer. As for its biological functions, PSA can no longer be regarded as a specific prostate molecule associated mainly with semen liquefaction when it has a possible role as a prognostic indicator in female breast cancer. The biological role of PSA in normal tissues and tumors may be much more complex than previously thought and requires further investigation. |
| Databáze: | OpenAIRE |
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